Role of Bacteria Overlooked in Mental Disorders

Article excerpt

The past few years have seen numerous studies detailing the effect that the brain can have on gut bacteria (top-down control). It is known, for instance, that stress might modulate intestinal microbiota. However, recent research - much of it preclinical - suggests that the contrary also is true: Gut bacteria can influence the brain. These new findings are very important, for they justify consideration of patients' gastrointestinal health while treating psychiatric disorders.

A recent article published by Dr. Serguei O. Fetissov and Dr. Pierre Dechelotte in France, for example, suggests that eating disorders, major depressive disorder, and narcolepsy might originate outside the brain and might be a dysfunction of the "gutbrain axis involving the humoral immune system" (Curr. Opin. Clin. Nutr. Metab. Care 2011;14:477-82). Some of the strongest evidence of this connection can be found in eating disorders.

Dr. Fetissov and Dr. Dechelotte propose that the composition of the gut microbiome might represent a "key causative factor triggering production of certain neuropeptide-reactive autoAbs, which in turn will modulate corresponding peptidergic signaling resulting in modification of eating-related behaviors and eventual. Another study, by Dr. K.M. Neufeld and colleagues at McMaster University, Hamilton, Ont., indicates that intestinal microbiota play a role in the development of the central nervous system and behavior. They evaluated the basic behavioral characteristics of germ-free versus specific pathogen-free adult mice. The former have been found to show a hyper responsive hypothalamic-pituitary-adrenal axis following stress, compared with regular laboratory mice (specific pathogen-free mice). However, actual behavior had not been previously evaluated. Interestingly enough, Dr. Neufeld's study found that germ-free mice showed decreased anxiety. They engaged in risky behavior more often and for longer periods of time than did regular mice (specific pathogen-free mice). Germ-free mice also exhibited an up-regulation of the brain-derived neurotrophic factor in the dentate gyrus of the hippocampus, as well as down-regulation of 5HT1A receptors and NMDA receptor expression, all of which have been associated to the stress response and to emotional behavior (Neurogastroenterol. …