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A new treatment mimics the pain-blocking mechanism of acupuncture and offers longer-lasting relief, at least in mice.

Injecting an enzyme called PAP into an acupuncture point behind the knees of mice relieved pain caused by inflammation for up to six days, Julie Hurt and Mark Zylka of the University of North Carolina at Chapel Hill report online April 23 in Molecular Pain. That's almost 100 times as long as pain relief from acupuncture, which typically lasts about 1 1/2 hours.

"The beauty of Mark's study is that it takes advantage of the molecular mechanism of acupuncture and improves upon it," says Maiken Nedergaard, a neuroscientist at the University of Rochester …