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A hotel room here. Dozens of excessive cab fares there. A government-discount plane ticket for the wife. For five years, Food and Drug Administration chief David A. Kessler submitted expense accounts riddled with nickel-and-dime charges in his favor, a review of records shows.

Confronted with travel vouchers that were signed as truthful under penalty of federal law, Kessler insisted Friday that the errors were unintentional, and he has written an $850 check to cover anything he owes the government.

"Even while things are being corrected and so there can't be any questions, I've reimbursed the government based on preliminary figures," said Kessler, whose annual …