CHYMOTRYPSIN

kīˌmōtrĭpˈsĭn, proteolytic, or protein-digesting, enzyme active in the mammalian intestinal tract. It catalyzes the hydrolysis of proteins, degrading them into smaller molecules called peptides. Peptides are further split into free amino acids. Chymotrypsin is produced in the pancreas as the inactive, or zymogen, form chymotrypsinogen. Along with other digestive enzymes of the pancreas, chymotrypsinogen is carried in the pancreatic juice through the pancreatic duct into the duodenum. There chymotrypsinogen is activated by another enzyme, trypsin, and by molecules of active chymotrypsin. Partly because it was one of the first enzymes available commercially in crystalline form, chymotrypsin has been studied extensively.

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Questia Books and Articles on: Chymotrypsin
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books on: Chymotrypsin  - 50 results

       More book Results: 1-10 11-20 21-30 31-40 41-50 >>  
 
1.
Origins of Life on the Earth and in the Cosmos
Book by Geoffrey Zubay; Academic Press, 2000
Subjects: Life--Origin
...present in the other two enzymes, with chymotrypsin having one more disulfide bridge and...during digestion is bound. Trypsin, chymotrypsin, and elastase share not only a common...diagrams of the amino acid sequences of chymotrypsin, trypsin, and elastase. Each circle...
2.
Subcellular Particles: A Symposium Held during the Meeting of the Society of General Physiologists at the Marine Biological Laboratory, Woods Hole, Massachusetts, June 9-11, 1958
Book by Teru Hayashi; Ronald Press Co., 1959
Subjects: Cytology
...about these phenomena. The action of chymotrypsin on substrate adsorbed on kaolinite...a rate comparable to the action of chymotrypsin on the same substrate in solution...solution. Addition of substrate to chymotrypsin previously adsorbed on kaolinite resulted...
3.
The Structure and Function of Muscle
Book by G. H. Bourne; Academic Press, 1960
Subjects: Muscles
...properties are concerned. These enzymes are chymotrypsin Gergely et al ., 1955 , subtilisin...slightly different loci when trypsin or chymotrypsin acts. Still, C-terminal groups...specificity requirements of trypsin or chymotrypsin are not found in a mole to mole ratio...
4.
Classic Papers in Genetics
Book by James A. Peters; Prentice-Hall, 1959
Subjects: Genetics
...were added crystalline trypsin and chymotrypsin or combinations of both, suffered...activity. The fact that trypsin, chymotrypsin, and ribonuclease had no effect on...the samples of crystalline trypsin, chymotrypsin, and ribonuclease used in this work...
5.
The Origin of Life on the Earth
Book by A. I. Oparin, Ann Synge; Academic Press, 1957
Subjects: Chemistry, Physical and theoretical, Life--Origin, Matter--Properties
...facts about the chemical structure of chymotrypsin and pepsin. Comparative study by blocking...isopropyl fluorophosphate combines with chymotrypsin but not with its precursor. When this...also necessary for the activity of chymotrypsin. In just the same way the proteolytic...
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journal articles on: Chymotrypsin  - 20 results

       More journal Results: 1-10 11-20 >>  
 
1.
Mass Spectrometric Analyses of Organophosphate Insecticide Oxon Protein Adducts
Journal article by Charles M. Thompson, John M. Prins, Kathleen M. George; Environmental Health Perspectives, Vol. 118, 2010
Subjects: Mass spectrometry--Usage, Occupational health and safety--Research, Occupational safety and health--Research, Organophosphate insecticides--Health aspects, Organophosphate insecticides--Research, Organophosphate insecticides--Structure
...into peptide fragments (trypsin, chymotrypsin, etc.); the peptides are analyzed...tyrosine (Y) at the N-terminus, and chymotrypsin (cleaves at F, W, or Y at the C...of different sizes after trypsin and chymotrypsin digests. Different sources of cholinesterase...
2.
Joseph S. Fruton
Journal article by Maxine Singer, Sidney Altman; Proceedings of the American Philosophical Society, Vol. 153, 2009
Subjects: Biology, Books, Chemistry, Enzymes, Medical research, Political appointments, Proteins, Students, Studies
...bond and confirmation of this with chymotrypsin. Fruton later called these reactions...specificity of crystalline trypsin and chymotrypsin, and later of pepsin. These elegant...proteases. Transpeptidation by papain and chymotrypsin was of continuing interest, especially...
3.
Protein Digestibility and Relevance to Allergenicity
Journal article by Gary Bannon, Tong-Jen Fu, Ian Kimber, Dennis M. Hinton; Environmental Health Perspectives, Vol. 111, 2003
Subjects: United States. Food and Drug Administration
...h2 protein was exposed to trypsin, chymotrypsin, or pepsin, either before or after...epitopes, the protein was exposed to chymotrypsin, and the reactions were electrophoresed...fragment also contains 11 potential chymotrypsin cleavage sites. These results demonstrate...
4.
Toxins and Other Bioactive Compounds Produced by Cyanobacteria in Lake Ladoga/tsuanobakterite Poolt Produtseeritavate Toksiinide Ja Muude Bioloogiliselt Aktiivsete Uhendite Mitmekesisus Laadoga Jarves
Journal article by Ludmila Voloshko, Jiri Kopecky, Tatiana Safronova, Alla Pljusch, Nina Titova, Pavel Hrouzek, Valentina Drabkova; Estonian Journal of Ecology, Vol. 57, 2008
Subjects: Cyanobacteria--By-products, Toxins--Environmental aspects, Toxins--Health aspects
...identified 9 different protease and chymotrypsin inhibitors in the natural samples...Kaya, K. 1995. Oscillamide Y, a chymotrypsin inhibitor from toxic Oscillatoria agardhii...protease <br/ inhibitor; ChTI, chymotrypsin inhibitor) <br/ m/z <br/ M...
5.
The Favorable Features of Tryptophan Synthase for Proving Beadle and Tatum's One Gene-one Enzyme Hypothesis
Journal article by Charles Yanofsky; Genetics, Vol. 169, 2005
Subjects: Deoxyribonucleic acid--DNA, Enzymes, Genes, Genetic engineering, Molecular biology, Mutation, Proteins, Tryptophan Synthase
...purification. Each mutant protein was then digested with trypsin, chymotrypsin, or both, and 2D fingerprints of the peptide digests were...removed, and the total protein hydrolyzed with trypsin or chymotrypsin. The resulting peptides were then separated by high-voltage...
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magazine articles on: Chymotrypsin  - 6 results

       More magazine Results: 1-6 >>  
 
1.
Got Proteasomes?
Magazine article by Laura Lane; The Scientist, Vol. 16, July 8, 2002
...sites located in the P rings. Two of the sites act like chymotrypsin, which cleaves after hydrophobic residues; two trypsin...presented in spite of proteasome inhibitors that block the chymotrypsin-like active sites Alternatively, the trypsin-like and...
2.
Going beneath the Fold
Magazine article by Robert Mahley, Yadong Huang; The Scientist, Vol. 20, August 2006
...apoE is synthesized by neurons, the 27 carboxyl-terminal amino acids can be lopped off the end by a neuron-specific, chymotrypsin-like serine protease.12-14 Because of its unique conformation (domain interaction), apoE4 is much more susceptible...
3.
New Drugs of 1993 - Part 2
Magazine article by Ronald F. Borne, Michael C. Vinson; Drug Topics, Vol. 138, March 7, 1994
Subjects: Boehringer Mannheim Corp, Drugs, Manycompanies, Manyproducts, Ortho Pharmaceutical Corp, SmithKline Beecham, United States, Warner-Lambert Co, Wyeth-Ayerst Laboratories
...complex: It inhibits serine proteases, including plasmin and kallikrein (thus direct affecting fibrinolysis), trypsin, chymotrypsin, and plasmin-streptokinase through the formation of reversible enzyme-inhibitor complexes. In addition, it inhibits...
4.
Researchers Report Winners, Losers in Battle against Ibd
Magazine article by Fred Gebhart; Drug Topics, Vol. 146, June 17, 2002
Subjects: Bowel disease, Clinical trials, Drug therapy, United States
...induce remission. Bowman-Birk protease inhibitor concentrate (BBIC) inhibits human serine proteases, including trypsin, chymotrypsin, elastase, cathepsin G, and mast cell chymase. Patients in the double-blind, placebo-controlled trial took four...
5.
The Post Investigates the Pancreas
Magazine article by Patrick Perry, Cory Servaas, Dick Bott; The Saturday Evening Post, Vol. 273, September 2001
Subjects: Cancer, Medical research, Medical technology, Pancreas, Series & special reports
...If all doesnt go well after the Whipple operation and the pancreas becomes inflamed, its digestive enzymes-trypsin and chymotrypsin, which help digest protein-can leak from the rejoined bile and pancreatic ducts and start attacking the tissue that produces...
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encyclopedia articles on: Chymotrypsin  - 8 results

       More encyclopedia Results: 1-8 >>  
 
1.
Chymotrypsin
Encyclopedia article; The Columbia Encyclopedia, Sixth Edition, 2009
CHYMOTRYPSIN ki motrip sin, proteolytic, or protein...further split into free amino acids . Chymotrypsin is produced in the pancreas as the...trypsin, and by molecules of active chymotrypsin. Partly because it was one of the...
2.
Trypsin
Encyclopedia article; The Columbia Encyclopedia, Sixth Edition, 2009
...proteinases, the other two being pepsin and chymotrypsin . In the digestive process, trypsin...other chief pancreatic proteinase, chymotrypsin. Both enzymes also appear to have...acids are arginine and lysine, for chymotrypsin they are tyrosine, phenylalanine...
3.
Serine
Encyclopedia article; The Columbia Encyclopedia, Sixth Edition, 2009
...enzymes, serine often plays an important role in their catalytic function. It has been shown to occur in the active sites of chymotrypsin , trypsin , and many other enzymes. The so-called nerve gases and many substances used in insecticides have been shown...
4.
Northrop, John Howard
Encyclopedia article; The Columbia Encyclopedia, Sixth Edition, 2009
...crystallized, Northrop isolated and crystallized a number of biologically important enzymes, including pepsin, trypsin, chymotrypsin, ribonuclease, and deoxyribonuclease, and provided indisputable evidence that they are proteins...
5.
Histidine
Encyclopedia article; The Columbia Encyclopedia, Sixth Edition, 2009
...thought that the side chain of this amino acid acts as a general acid and base as it participates in the catalytic functions of chymotrypsin , as well as those of a number of enzymes dealing with the metabolism of carbohydrates, proteins, and nucleic acids. It...
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