COLCHICINE

kŏlˈchəsēnˌ, alkaloid extracted from plants of the genus Colchicum and especially from the corms of the autumn crocus, Colchicum autumnale (see meadow saffron). The metabolic effect of colchicine is not known, but it is thought that it may decrease production of lactic acid and prevent accumulation of uric acid crystals in the body, making it useful in the treatment of gout. Colchicine and derivatives such as demecolcine inhibit mitosis, or cell division. As a mitotic poison, it inhibits rapidly proliferating cells and has been used in cancer therapy and as an immunosuppressive drug. Colchicine has also been used to visualize chromosomes photomicrographically and to induce mutations experimentally.

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The Columbia Encyclopedia, Sixth Edition Copyright© 2004, Columbia University Press. Licensed from Lernout & Hauspie Speech Products N.V. All rights reserved.

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Questia Books and Articles on: Colchicine
We found: 226 results
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122  

 

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51  

 

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books on: Colchicine  - 122 results

       More book Results: 1-10 11-20 21-30 31-40 41-50 >>  
 
1.
Molecularizing Biology and Medicine: New Practices and Alliances, 1910s-1970s
Book by Soraya De Chadarevian, Harmke Kamminga; Harwood Academic, 1998
Subjects: Molecular Biology--History--20th Century, Pathology, Molecular--History--20th Century
...Wellensiek published their survey of colchicine with their version of events supporting...the first book-length treatment of colchicine that appeared in 1955, they discussed...What was at stake in this part of the colchicine story? ENTRACTE Colchicine was fundamentally...
2.
Fifty Years of Botany: Golden Jubilee Volume of the Botanical Society of America
Book by William Campbell Steere; McGraw-Hill, 1958
Subjects: Botany
...AND J. LOUDON. 1951. Alkaloids: Colchicine. Ed. by Holmes and Manske. Vol...Monthly 70:211-219. DERMEN H. 1940. Colchicine, polyploidy and technique. Bot. Rev...AND F. LITS. 1937. Action de la colchicine sur les divisions cellulaires chez les...
3.
Introduction to Genetics and Cytogenetics
Book by Herbert Parkes Riley; John Wiley & Sons, 1948
Subjects: Cytogenetics
...made to induce polyploidy by the use of colchicine. As in plants, the formation of the...have been produced as the result of colchicine treatment, but they have not lived long or produced polyploid organisms. When colchicine was applied to eggs of Arbacia punctata...
4.
Structural Aspects of Cell Physiology
Book by Society for Experimental Biology; Academic Press, 1952
Subjects: Cells
...the dividing cell to the effects of colchicine is illustrated by comparison of the...of the spindle are affected both by colchicine and by substances such as the narcotics. Thus colchicine is without influence on cyclosis in...
5.
An Outline of General Physiology
Book by L. V. Heilbrunn; W. B. Saunders, 1952
Subjects: Physiology
...have been interested in the effect of colchicine on mitosis. This alkaloid in dilute...can be induced, and with the aid of colchicine, horticulturists have been able to...various plants. The explanation of the colchicine effect is clear. Colchicine acts like...
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journal articles on: Colchicine  - 51 results

       More journal Results: 1-10 11-20 21-30 31-40 41-50 >>  
 
1.
Misregulation of the Kinesin-like Protein Subito Induces Meiotic Spindle Formation in the Absence of Chromosomes and Centrosomes
Journal article by Janet K. Jang, Taslima Rahman, Vanessa S. Kober, Jeffry Cesario, Kim S. McKim; Genetics, Vol. 177, 2007
Subjects: Cellular biology, Drosophila Proteins, Kinesin, Motors, Proteins, subito protein, Drosophila
...incubated in 50 l/ml of 10^sup -3^ m colchicine solution in Robbs buffer for 1 hr prior...for 1 hr in buffer (Robbs) without colchicine. When examining sub mutant oocytes...importance by treating stage 14 oocytes with colchicine to depolymerize the microtubules. All...
2.
Off-label Prescription Advertising, the FDA and the First Amendment: a Study in the Values of Commercial Speech Protection
Journal article by Coleen Klasmeier, Martin H. Redish; American Journal of Law and Medicine, Vol. 37, 2011
Subjects: Advertising restrictions, Commercial speech, FDA approval, Medical equipment, Public health
...similar track records. The gout drug colchicine is a case in point. Before the 2006...manufactured and/or sold single-ingrethent colchicine tablets without FDA approval. After...approval for its single-ingrethent colchicine tablets, and the manufacturers drug...
3.
Developmental and Cell Cycle Progression Defects in Drosophila Hybrid Males
Journal article by Bonnie J. Bolkan, Ronald Booker, Michael L. Goldberg, Daniel A. Barbash; Genetics, Vol. 177, 2007
Subjects: Apoptosis, Chromosomes, Drosophila Proteins, Environmental conditions, Genes, Genetics, Insects, Males, Studies, hybrid male rescue protein, Drosophila
...both the presence and the absence of colchicine (a drug used to arrest cells in metaphase...brains were incubated in 0.5 3 10-5 m colchicine in 0.7% NaCl for 0.5, 1, or 2...males, we cultured larval brains in colchicine, a drug that inhibits microtubule polymerization...
4.
Diagnosis and Treatment of Alcoholic Liver Disease and Its Complications
Journal article by Luis S. Marsano, Christian Mendez, Daniell Hill, Shirish Barve, Craig J. Mcclain; Alcohol Research & Health, Vol. 27, 2003
...enthusiasm for PTU as a treatment for ALD. Colchicine. Because of its antifibrotic effects, colchicine has been suggested as a treatment for...large VA Cooperative Study evaluating colchicine therapy in patients with alcoholic cirrhosis...
5.
Contribution of Growth and Cell Cycle Checkpoints to Radiation Survival in Drosophila
Journal article by Burnley Jaklevic, Lyle Uyetake, Willy Lemstra, Julia Chang; Genetics, Vol. 174, 2006
Subjects: Antineoplastic Agents, Phytogenic, Camptothecin, Cancer, Cell Cycle Proteins, Cell cycle, Checkpoint kinase 1, Cisplatin, DNA damage, DNA repair, Drosophila Proteins, Genetics, Insects, Intercellular Signaling Peptides and Proteins, Kinases, Protein Kinases, Protein-Serine-Threonine Kinases, Proteins, RNA, Small Interfering, Radiation, Radiation-Sensitizing Agents, meiotic 41 protein, Drosophila
...diet is 20% sucrose (w/v) in PBS. Colchicine and small molecules were mixed into...microtubule depolymerization agent, colchicine, to interfere with mitotic proliferation...irradiated and then fed food containing colchicine. If compensatory proliferation was...
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magazine articles on: Colchicine  - 22 results

       More magazine Results: 1-10 11-20 21-22 >>  
 
1.
Superpotent Colchicine Recalled
Magazine article; Drug Topics, Vol. 145, January 15, 2001
Superpotent Colchicine Recalled Phyne Pharmaceuticals of Scottsdale, Ariz., has issued...products due to a lack of assurance of sterility and a mislabeling of colchicine as .5 mg/ml when it is actually a superpotent 5 mg/ml. The products...
2.
Gout: a Therapeutic Update
Magazine article by Christina Coakley, Dana A. Brown; Drug Topics, Vol. 154, November 2010
Subjects: Medical treatment, Pharmacists, Rheumatism, United States
...hypersensitivity to aspirin or other NSAIDs.3-812 Colchicine. Colchicine has an indication for both the treatment and prevention...do not receive symptom resolution from NSAIDs.3 Colchicine is strictly an anti- inflammatory medication and...
3.
Arthritis: Exploring the Alternatives (An Interview with Dale Guyer, M.d.)
Magazine article by Joan Servaas; The Saturday Evening Post, Vol. 272, November 2000
Subjects: Arthritis, Brummett, Debbie, Guyer, Dale, Health care
...infinitely helpful is the medicine colchicine, which is used to treat individuals with gout. We use colchicine quite frequently in my practice administered...after just a couple of injections with colchicine. It is basically an herbal medicine...
4.
Getting to Know Gout
Magazine article by Ken Flieger; FDA Consumer, Vol. 29, March 1995
Subjects: Gout--Care and treatment
...to be effective against acute gout is colchicine, which comes from a common European...exaggeration, but a rapid response to colchicine suggests that the patient does indeed...against acute gout and less toxic than colchicine. To treat an acute case of gout, the...
5.
FDA Launches Educational Videos for Pharmacists
Magazine article by Christine Blank; Drug Topics, Vol. 154, July 2010
Subjects: FDA approval, Health education, Pharmaceuticals, Pharmacists, United States
...is tackling unapproved dispensing of colchicine. The Drug Info Rounds series seeks...approved the first single-ingrethent oral colchicine, Colcrys, for acute gout flares and...market, the FDA video warns, because colchicine predates existing FDA laws and regulations...
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newspaper articles on: Colchicine  - 25 results

       More newspaper Results: 1-10 11-20 21-25 >>  
 
1.
Has Colchicine Been Nixed by Doctors?
Newspaper article; Daily Herald (Arlington Heights, IL), January 24, 2011
Subjects: Colchicine, Physicians
Has Colchicine Been Nixed by Doctors? Q. I was in...prescriptions, and he indicated that colchicine is being pulled from the market. I...suggestions? A. As you are aware, oral colchicine is prescribed either to prevent attacks...
2.
Oldie but Goodie Still Does the Trick for Gout
Newspaper article; Daily Herald (Arlington Heights, IL), July 13, 2009
Subjects: Colchicine, Gout
...the normal size. My doctor prescribed colchicine with directions to take one every four...and may include medications such as colchicine, allopurinol and nonsteroidal anti...This was obviously the case with the colchicine your physician prescribed. Side effects...
3.
Go Exotic in Autumn; DOUBLE ACT: The Lilac and Crocus-Like Colchicum 'Waterlily' Flowers in Autumn with Wide Architectural Foliage Following in Spring
Newspaper article; The Mail on Sunday (London, England), July 22, 2007
Subjects: Colchicine, Flowers
4.
Changes in Diet Can Solve Gout; HEALTHMATTERS YOUR MEDICAL QUERIES ANSWERED
Newspaper article; South Wales Echo (Cardiff, Wales), April 1, 2010
Subjects: Diet, Gout, Purines
...pain and reduce swelling. If an anti-inflammatory drug is not tolerated, a different medication called Colchicine can be given. Colchicine improves symptoms of gout by reducing the amount of uric acid in the blood, although the number of side...
5.
Crocus Drug That Can Kill Tumours in One Treatment
Newspaper article; The Daily Mail (London, England), September 12, 2011
Subjects: Cancer treatment, Cancer--Care and treatment, Drugs, Pharmaceutical industry, Tumors
...Science Festival will hear this week. The drug, based on colchicine, an extract from the autumn crocus, is at an early stage...of a combination of therapies to treat and manage cancer. Colchicine has long been known to have anti-cancer properties but has...
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encyclopedia articles on: Colchicine  - 6 results

       More encyclopedia Results: 1-6 >>  
 
1.
Colchicine
Encyclopedia article; The Columbia Encyclopedia, Sixth Edition, 2009
COLCHICINE kol ch sen , alkaloid extracted from...saffron ). The metabolic effect of colchicine is not known, but it is thought that...it useful in the treatment of gout. Colchicine and derivatives such as demecolcine...
2.
Blakeslee, Albert Francis
Encyclopedia article; The Columbia Encyclopedia, Sixth Edition, 2009
...information concerning chromosome behavior, genic balance, and species evolution. He introduced the use of the alkaloid colchicine to increase the number of chromosomes in the plant cell. ____________________ Copyright 2009 Columbia...
3.
Gout
Encyclopedia article; The Columbia Encyclopedia, Sixth Edition, 2009
...treated with nonsteroidal anti-inflammatory drugs, such as indomethecine or naproxen, or the corticosteroid prednisone. Colchicine, a preparation of the meadow saffron , used since 1763 for gout, is still used when symptoms are not controlled by other...
4.
Meadow Saffron
Encyclopedia article; The Columbia Encyclopedia, Sixth Edition, 2009
...gardens to meadows and fields in some parts of the United States. Its poisonous corms and seeds were the source of the drug colchicine . The purplish flowers, which bloom in the fall when the leaves are gone, resemble those of the true crocus and true saffron...
5.
Medicine
Encyclopedia article; The Columbia Encyclopedia, Sixth Edition, 2009
...developed in ancient Egypt, and involved the use of many potent drugs still in use today, such as castor oil, senna, opium, colchicine, and mercury. In spite of their skill in embalming, however, the Egyptians had little knowledge of anatomy. In Sumerian...
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