PROTEASE INHIBITOR

prōˈtē-āsˌ, any of a class of drugs that interfere with replication of the AIDS virus (HIV), by blocking an enzyme (protease) necessary in the late stages of its reproduction. Clinical trials of the protease inhibitor indinavir have shown it to be especially beneficial in combination with the anti-HIV drugs AZT and 3TC, which act by blocking a different enzyme, reverse transcriptase. Saquinavir, the first member of the class to be marketed, was approved for use in 1995 by the Food and Drug Administration.

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The Columbia Encyclopedia, Sixth Edition Copyright© 2004, Columbia University Press. Licensed from Lernout & Hauspie Speech Products N.V. All rights reserved.

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Questia Books and Articles on: Protease Inhibitor
We found: 574 results
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97  

 

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262  

 

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books on: Protease Inhibitor  - 97 results

       More book Results: 1-10 11-20 21-30 31-40 41-50 >>  
 
1.
AIDS in Europe: New Challenges for the Social Sciences
Book by Jean-Paul Moatti, Yves Souteyrand, Annick Prieur, Theo Sandfort, Peter Aggleton; Routledge, 2000
Subjects: Aids (Disease)--Social Aspects--Europe
...attitude towards protease inhibitor-containing...term effects of protease inhibitor therapy...as follows: one protease inhibitor and two NRTIs N =36 ; two protease inhibitors N =3 ; two protease...two protease inhibitors and two NRTIs N =1 ; one protease inhibitor, two NRTIs and...
2.
Power in the Blood: A Handbook on AIDS, Politics, and Communication
Book by William N. Elwood; Lawrence Erlbaum Associates, 1999
Subjects: Aids (Disease)--Social Aspects--United States
...AIDS TREATMENTS: PROTEASE INHIBITORS Standards...drugs called protease inhibitors. Protease inhibitors block a part of HIV...along with a protease inhibitor e.g., Crixivan...major concern with protease inhibitors. If the virus becomes...resistance to one protease inhibitor, it will be resistant...
3.
The $800 Million Pill: The Truth behind the Cost of New Drugs
Book by Merrill Goozner; University of California Press, 2004
Subjects: Consumer Education, Drugs--Prices, Pharmaceutical Industry, Prescription Pricing
...It was concrete evidence that a protease inhibitor actually worked in humans. All...felt pressure to show that his protease inhibitor could work. Abbott...government help to fund its initial protease inhibitor research. But that...
4.
Hepatitis C, the Silent Epidemic: The Authoritative Guide
Book by Fred K. Askari, Daniel S. Cutler; Perseus Books, 1999
Subjects: Hepatitis C--Popular Works
...The introduction of HIV protease inhibitors brought about...infected with HIV. The HIV protease inhibitors are able to decrease...piece of these cocktails is a protease inhibitor, with names such as Saquinavir...be before we have protease inhibitors available for therapy that...
5.
Communicating Uncertainty: Media Coverage of New and Controversial Science
Book by Sharon M. Friedman, Sharon Dunwoody, Carol L. Rogers; Lawrence Erlbaum Associates, 1999
Subjects: Discoveries In Science, Mass Media--Audiences, Science In Mass Media, Science News
...wanted a definition of a protease inhibitor: I have no idea...combination, the protease inhibitor . . . is having this effect...know what that the protease inhibitor is and I would be interested...to HIV, what a protease inhibitor was, what AZT is, all kinds...to get it the new protease inhibitors ? Why not give it first if...
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journal articles on: Protease Inhibitor  - 262 results

       More journal Results: 1-10 11-20 21-30 31-40 41-50 >>  
 
1.
Targeted Gene Deletion and Phenotypic Analysis of the Drosophila Melanogaster Seminal Fluid Protease Inhibitor Acp62f
Journal article by Jacob L. Mueller, Jon R. Linklater, Kristipati Ravi Ram, Tracey Chapman, Mariana F. Wolfner; Genetics, Vol. 178, 2008
Subjects: Acp26Aa protein, Drosophila, Circulatory system, Competition, Drosophila Proteins, Females, Genetics, Males, Peptides, Protease Inhibitors, Protease inhibitors, Proteins, Roles, Scholarships & fellowships, Seminal Plasma Proteins, accessory gland peptide 62F, Drosophila
...Melanogaster Seminal Fluid Protease Inhibitor Acp62f by Jacob...male and female proteases and protease inhibitors. Seminal fluid...predicted serine protease inhibitors, and some of these protease inhibitor Acps target to...
2.
Diversity-enhancing Selection Acts on a Female Reproductive Protease Family in Four Subspecies of Drosophila Mojavensis
Journal article by Erin S. Kelleher, Nathaniel L. Clark, Therese A. Markow; Genetics, Vol. 187, 2011
Subjects: Animal reproduction, Evolution, Females, Genetics, Males, Studies
...determinants of protease inhibitor susceptibility...susceptibility of female proteases to inhibitors in the male ejaculate...If female proteases interact and coevolve with male protease inhibitors, selected...susceptibility to protease inhibitors. Consistent with...important to protease inhibitor susceptibility...
3.
Mutations in Genes Encoding Sorting Nexins Alter Production of Intracellular and Extracellular Proteases in Aspergillus Nidulans
Journal article by Margaret E. Katz, Cara J. Evans, Emma E. Heagney, Patricia A. Vankuyk, Joan M. Kelly, Brian F. Cheetham; Genetics, Vol. 181, 2009
Subjects: Apoptosis, Enzymes, Microbiology, Mutation, Proteins
...of the effect of protease inhibitors, the gels were...containing the inhibitor for 60 min on a...of extracellular proteases, samples of filtered...nidulans, four proteases (a, b, g, and...electrophoretic mobility, inhibitor sensitivity, substrate...Extracellular proteases g and e were susceptible to serine protease inhibitors and are similar...
4.
The Protease Activity of Yeast Separase (Esp1) Is Required for Anaphase Spindle Elongation Independently of Its Role in Cleavage of Cohesin
Journal article by Chris Baskerville, Marisa Segal, Steven I. Reed; Genetics, Vol. 178, 2008
Subjects: Cell Cycle Proteins, Cell cycle, Cell division, Chromosomal Proteins, Non-Histone, Endopeptidases, MCD1 protein, S cerevisiae, Nuclear Proteins, Peptides, Phosphoproteins, Proteins, Saccharomyces cerevisiae Proteins, Substrates, cohesins, separase
...sub 3^, and complete protease inhibitor cocktail (catalog no...within Mcd1 with a TEV protease cleavage site was created...Sse) encoding the protease catalytic domain and...substrate-mimetic inhibitor does not inhibit association...
5.
Drosophila Signal Peptide Peptidase Is an Essential Protease for Larval Development
Journal article by David J. Casso, Soichi Tanda, Brian Biehs, Bruno Martoglio, Thomas B. Kornberg; Genetics, Vol. 170, 2005
Subjects: Aspartic Endopeptidases, Enzymes, Genes, Genomics, Proteins, signal peptide peptidase
...homology with human aspartyl protease SPP (WEIHOFEN et al. 2002...WEIHOFEN et al. 2002). This protease inhibitor was shown to block signal...signal peptidase or other proteases such as cathepsin or the...whether the predicted aspartyl protease activity of SPP was responsible...
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magazine articles on: Protease Inhibitor  - 197 results

       More magazine Results: 1-10 11-20 21-30 31-40 41-50 >>  
 
1.
Protease Inhibitors Turn 1
Magazine article by John Gallagher; The Advocate, September 2, 1997
Subjects: AIDS (Disease)--Drug therapy, Diseases, Gay men--Diseases, HIV infection--Care and treatment, HIV infections--Care and treatment, Protease inhibitors--Usage
Protease Inhibitors Turn 1. by John Gallagher...affair with the protease inhibitor, a powerful class of...began taking protease inhibitors last December to combat...including a different protease inhibitor--but with even worse...
2.
New Protease Inhibitor Offers Favorable Resistance Pattern
Magazine article by Elena Portyansky; Drug Topics, Vol. 143, May 17, 1999
Subjects: Glaxo Wellcome Inc, HIV, Prescription drugs, Product introduction, United States
New Protease Inhibitor Offers Favorable...A new protease inhibitor, granted accelerated...most protease inhibitors, Agenerase...other protease inhibitors appears to be...observed in protease inhibitor therapy-experienced...
3.
New Protease Inhibitor Put on Expanded Access
Magazine article by Jean McCann; Drug Topics, Vol. 140, October 7, 1996
Subjects: AIDS, HIV, Prescription drugs, United States
New Protease Inhibitor Put on Expanded...A new protease inhibitor (nelfinavir mesylate...other protease inhibitors. We predict about...of the protease inhibitors. When used in...newest protease inhibitor might differ from...
4.
Let Them Eat Protease Inhibitors
Magazine article by Susan Warner; The Scientist, Vol. 18, June 21, 2004
Let Them Eat Protease Inhibitors by Susan Warner Activists campaigning to get AIDS treatments and other critical medicines to poor people around the world propose...
5.
Financial Inhibitors
Magazine article by John Gallagher; The Advocate, September 16, 1997
Subjects: AIDS (Disease)--Care and treatment, Medical care--Finance, Protease inhibitors--Finance
Financial Inhibitors. by John Gallagher Last...Advocate explained why protease inhibitors dont work for...usually comes with potent protease inhibitors, capable of...advocating early use of protease inhibitors, the strain...
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newspaper articles on: Protease Inhibitor  - 16 results

       More newspaper Results: 1-10 11-16 >>  
 
1.
Pharmacies Sue Abbott over AIDS Drug Price
Newspaper article; Daily Herald (Arlington Heights, IL), October 31, 2007
Subjects: AIDS (Disease)--Cases, Abbott Laboratories (Abbott Park, Illinois)--Cases, American Sales Co.--Cases, Anti-HIV agents--Cases, Antiviral agents--Cases, Drug wholesalers--Cases, Drugstores--Cases, Kroger Co.--Cases, Norvir (Medication), Pharmaceutical industry--Cases, Protease inhibitors--Cases, SUPERVALU Inc.--Cases, Safeway Inc.--Cases, Supermarkets--Cases
...in a class of drugs called protease inhibitors which slow the spread of...protease enzymes. Protease inhibitors are one of three drugs used...effects of other protease inhibitors, including those made by...a non-Abbott (protease inhibitor). Norvir is sold at a much...
2.
US Regulators Approve New Hepatitis C Drug
Newspaper article; Manila Bulletin, May 16, 2011
Subjects: Drug approval, Hepatitis C--Drug therapy, Merck & Company Inc., Pharmaceutical industry, Protease inhibitors, United States. Food and Drug Administration
...known as Victrelis, to be taken with the current two-drug regimen. Also known as boceprevir, the drug is a protease inhibitor that prevents the liver-disease causing virus from multiplying and studies have shown it "significantly" boosts...
3.
Trial Drug Blocks HIV Enzyme; Integrase Inhibitor Drops Viral Levels in Monkeys
Newspaper article; The Washington Times, July 9, 2004
...Drug Blocks HIV Enzyme; Integrase Inhibitor Drops Viral Levels in Monkeys. Byline...the other two HIV enzymes, known as protease and reverse transcriptase. But until...monkeys treated immediately. "Integrase inhibitors represent a new class of drugs to treat...Merck is studying the same integrase inhibitor candidate in a small number of human...
4.
AIDS Deaths Continue Decline: All Risk Groups See Improvement
Newspaper article by Joyce Price; The Washington Times, July 15, 1997
...costly blockbuster drugs called protease inhibitors that have revolutionized AIDS...January 1996, before protease inhibitors were widely used. Because...stop her prescription for a protease inhibitor, saying "it was not his policy...
5.
Will U.S. Try to Circumvent Drug Firm's Patent?
Newspaper article; Daily Herald (Arlington Heights, IL), May 23, 2004
Subjects: Bayh, Birch, Thompson, Tommy G.
...of the same class, called protease inhibitors. This usage requires a much...to use Abbotts new protease inhibitor, Kaletra, which already contains...boosting agent." Competing protease inhibitors also perform far better when...
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encyclopedia articles on: Protease Inhibitor  - 2 results

 
 
1.
Protease Inhibitor
Encyclopedia article; The Columbia Encyclopedia, Sixth Edition, 2009
PROTEASE INHIBITOR pro te-as , any of a class of drugs...virus ( HIV ), by blocking an enzyme (protease) necessary in the late stages of its reproduction. Clinical trials of the protease inhibitor indinavir have shown it to...
2.
Aids , in Medicine
Encyclopedia article; The Columbia Encyclopedia, Sixth Edition, 2009
...reverse transcriptase inhibitors, have proved effective...individuals. The addition of a protease inhibitor , such as saquinovir...reverse transcriptase inhibitor, must be taken with protease inhibitors or older AIDS medicines...


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