PYRIMIDINE

pīrĭmˈĭdēnˌ, type of organic base found in certain coenzymes and in the nucleic acids of plant and animal tissue. The three major pyrimidines of almost universal distribution in living systems are cytosine, thymine, and uracil.

____________________

The Columbia Encyclopedia, Sixth Edition Copyright© 2004, Columbia University Press. Licensed from Lernout & Hauspie Speech Products N.V. All rights reserved.

-39232-

Top...
Search the Library
Books
Journals
Magazines
Newspapers
Encyclopedia
Advanced Search
About Questia
Questia is the world's largest online academic library offering full-text books, journals, and articles on thousands of topics.

Join Now...
Questia Books and Articles on: Pyrimidine
We found: 244 results
By media type:
 

Books:

 

140  

 

Journal articles:

 

81  

 

Magazine articles:

 

14  

 

Newspaper articles:

 

1  

 

Encyclopedia articles:

 

8  
 

books on: Pyrimidine  - 140 results

       More book Results: 1-10 11-20 21-30 31-40 41-50 >>  
 
1.
Origins of Life on the Earth and in the Cosmos
Book by Geoffrey Zubay; Academic Press, 2000
Subjects: Life--Origin
...bases and, to a lesser extent, from pyrimidine bases and their nucleosides. In this...PRPP GMP + PP;. (2) = BIOSYNTHESIS OF PYRIMIDINE NUCLEOTIDES The biosynthetic pathway to pyrimidine nucleotides is simpler than that for purine...
2.
Unity and Diversity in Biochemistry: An Introduction to Chemical Biology
Book by Marcel Florkin, T. Wood; Pergamon Press, 1960
Subjects: Biochemistry
...isomeric diamines: Pyridazine Pyrimidine Pyrazine To the organic chemist, pyrimidine derivatives are products...acid Barbituric acid 1. Pyrimidines Among the oxypyrimidines...uracil and thymine. Pyrimidine Uracil 2, 6-dioxy...
3.
Readings in Biological Science
Book by Irving William Knobloch; Appleton-Century-Crofts, 1967
Subjects: Biology
...chemically change a natural DNA pyrimidine or purine in such a way that its...an RNA virus. Here the natural pyrimidine, cytosine is converted to uracil, which is also a natural occurring pyrimidine in RNA. Adenine is oxidised to...
4.
Classic Papers in Genetics
Book by James A. Peters; Prentice-Hall, 1959
Subjects: Genetics
...the pair must be a purine and the other a pyrimidine for bonding to occur. The hydrogen bonds are made as follows: purine position 1 to pyrimidine position 1; purine position 6 to pyrimidine position 6.If it is assumed that the bases...
5.
J.D. Bernal: The Sage of Science
Book by Andrew Brown; Oxford University Press, 2006
Subjects: Bernal, J. D--(John Desmond)--1901-, Physicists--Great Britain--Biography
...confirmed Astburys assumption that the pyrimidine type of base found in DNA was a flat...data on bond lengths and angles for pyrimidine bases. A second PhD candi- date...of cytidine (which is formed by the pyrimidine base, cytosine, linking to a deoxyribose...
More book Results: 1-10 11-20 21-30 31-40 41-50 >>

Top...
 

journal articles on: Pyrimidine  - 81 results

       More journal Results: 1-10 11-20 21-30 31-40 41-50 >>  
 
1.
Quvr-10, a Major Quantitative Trait Locus for Ultraviolet-b Resistance in Rice, Encodes Cyclobutane Pyrimidine Dimer Photolyase
Journal article by Tadamasa Ueda, Tadashi Sato, Jun Hidema, Tokuhisa Hirouchi; Genetics, Vol. 171, 2005
Subjects: Amino acids, Chromosomes, DNA Primers, DNA repair, Deoxyribodipyrimidine Photo-Lyase, Genetic engineering, Pyrimidine Dimers, Rice
...b Resistance in Rice, Encodes Cyclobutane Pyrimidine Dimer Photolyase by Tadamasa Ueda , Tadashi...UVB causes DNA lesions, such as cyclobutane pyrimidine dimers (CPDs) and pyrimidine (6-4) pyrimidone photoproducts (6-4pps...
2.
Analysis of the Zebrafish Perplexed Mutation Reveals Tissue-specific Roles for de Novo Pyrimidine Synthesis during Development
Journal article by G. B. Willer, V. M. Lee, R. G. Gregg, B. A. Link; Genetics, Vol. 170, 2005
Subjects: Aspartate Carbamoyltransferase, CAD trifunctional enzyme, Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing), Cell Cycle Proteins, Cell adhesion & migration, Comparative analysis, Dihydroorotase, Females, Genetics, Glycosylation, Mutation, Pyrimidines, Retina, Zebrafish Proteins, perplexed protein, zebrafish, pyrimidine
...Tissue-specific Roles for de Novo Pyrimidine Synthesis during Development by...enzyme for de novo biosynthesis of pyrimidine-based nucleotides and catalyzes the first three steps in de novo pyrimidine biosynthesis (reviewed in JONES...
3.
Analysis of Pyrimidine Catabolism in Drosophila Melanogaster Using Epistatic Interactions with Mutations of Pyrimidine Biosynthesis and [Beta
Journal article by John M. Rawls Jr.; Vol. 172, 2006
Subjects: Animals, Genes, Genetics, Mutation, Signal transduction
...perturbed homeostasis of pyrimidines, ;2-alanine, or...demonstrated that modified pyrimidine degradation can be...mutants in which de novo pyrimidine biosynthesis is blocked...high dietary levels of pyrimidines and they are unable...first enzymatic step of pyrimidine degradation, DPD...
4.
The Relative Roles in Vivo of Saccharomyces Cerevisiae Pol [Chi
Journal article by Peter E. M Gibbs, John McDonald, Roger Woodgate, Christopher W. Lawrence; Vol. 169, 2005
Subjects: DNA Adducts, DNA Polymerase III, DNA damage, DNA polymerase zeta, DNA, Fungal, DNA-Directed DNA Polymerase, Deoxyribonucleic acid--DNA, Enzymes, Fungal Proteins, Genetic Vectors, Mutagens, Mutation, Nucleotidyltransferases, Plasmids, Pyrimidine Dimers, REV1 protein, S cerevisiae, Rad30 protein, Saccharomyces cerevisiae Proteins, Yeast
...7. Pol ;7, on the other hand, can not only efficiently bypass lesions capable of base pairing, such as cyclobutane pyrimidine dimers, and accurately insert correct nucleotides opposite them (JOHNSON et al. 1999; WASHINGTON et al. 2000), but...
5.
Chromosomal Fragmentation Is the Major Consequence of the Rdgb Defect in Escherichia Coli
Journal article by Lisa Lukas, Andrei Kuzminov; Genetics, Vol. 172, 2006
Subjects: DNA repair, DNA, Bacterial, Deoxyribonucleic acid--DNA, Escherichia coli Proteins, Genetic recombination, Purines, Pyrimidines, Pyrophosphatases, RdgB protein, E coli
More journal Results: 1-10 11-20 21-30 31-40 41-50 >>

Top...
 

magazine articles on: Pyrimidine  - 14 results

       More magazine Results: 1-10 11-14 >>  
 
1.
Pain and Rheumatoid Arthritis: an Update
Magazine article by Steven Chen, Mark A. Gill, Carolyn H. Luu, Sandra Takami; Drug Topics, Vol. 144, April 3, 2000
...immunosuppressant, immunomodulator), a pyrimidine synthesis inhibitor, was FDA-approved...dehydrogenase (DHODH), an enzyme required for pyrimidine synthesis. The inhibition of pyrimidine synthesis results in the interruption of...
2.
New Drug Approvals of 1998--part 1
Magazine article by W. Marvin Davis, I. Wade Waters; Drug Topics, Vol. 143, February 1, 1999
Subjects: Alcon Laboratories Inc, Astra Merck Inc, Continuing education, FDA approval, Glaxo Wellcome Inc, Information, Manycompanies, Manyproducts, Ony Inc, Pharmacists, Pharmacology, Prescription drugs, Product introduction, Roche Laboratories, Statistical data, United States
...previously been associated with fluorinated pyrimidine therapy-.g., electrocardiographic...as an inhibitor of the synthesis of pyrimidine bases essential to production of nucleic...dehydrogenase (an enzyme involved in de novo pyrimidine synthesis), imparting to it activity...
3.
Treatment Options Fo Rheumatiod Arthritis
Magazine article by Donald R. Miller; Drug Topics, Vol. 143, May 3, 1999
Subjects: Arthritis, Drug therapy, Pharmacists, United States
...inhibits the enzyme dihydro-orotate dehydrogenase, essential for synthesis of pyrimidine nucleotides. Activated T lymphocytes are especially dependent upon pyrimidine synthesis. Peak levels of the active metabolite occur six to 12 hours after...
4.
Pipeline 2011
Magazine article by Leah E. Perry; Drug Topics, Vol. 155, January 2011
Subjects: Business forecasts, Clinical trials, Medical treatment, Pharmaceutical industry, Research & development--R&D, United States
...later this year. Teriflunomide ( Sanofi- Aventis). Oral pyrimidine synthetase inhibitor and immunomodulator that reversibly inhibits...dihydroorotate dehydrogenase, a key enzyme involved in de novo pyrimidine synthesis. It is currently in phase 3 studies for the treatment...
5.
New Drugs of 1993: Part 1
Magazine article by Ronald F. Borne, Michael C. Vinson; Drug Topics, Vol. 138, February 7, 1994
Subjects: Alcon Laboratories Inc, Carter-Wallace Inc, Continuing education, Forest Laboratories Inc, Manycompanies, Manyproducts, Ortho Biotech Inc, Pharmacists, Prescription drugs, Product introduction, Schering-Plough Corp, Statistical data, United States
...causes a depletion of the energy source resulting in cell death. Cladribine differs from other antineoplastic purine and pyrimidine antimetabolites in that it affects resting as well as proliferating monocytes and lymphocytes. The sensitivity of monocytes...
More magazine Results: 1-10 11-14 >>

Top...
 

newspaper articles on: Pyrimidine  - 1 result

 
 
1.
Column to Address Effects, People Behind Technology
Newspaper article by Fred Reed; The Washington Times, November 12, 2001
...seems to stick. My alleged mind just works that way. So I know about partial derivatives and TCP/IP headers and purine-pyrimidine stereochemistry in the DNA ladder and the parts of a transistor and where oxytocin and vasopressin come from and how a PET...


Top...
 

encyclopedia articles on: Pyrimidine  - 8 results

       More encyclopedia Results: 1-8 >>  
 
1.
Pyrimidine
Encyclopedia article; The Columbia Encyclopedia, Sixth Edition, 2009
PYRIMIDINE pirim iden , type of organic base found in certain coenzymes and in the nucleic acids of plant and animal tissue. The three major pyrimidines of almost universal distribution in living systems are cytosine , thymine...
2.
Thymine
Encyclopedia article; The Columbia Encyclopedia, Sixth Edition, 2009
THYMINE thi men, organic base of the pyrimidine family. Thymine was the first pyrimidine to be purified from a natural source, having...systems; such is not the case with the other pyrimidines. The nucleotide derivatives of thymine do...
3.
Kossel, Albrecht
Encyclopedia article; The Columbia Encyclopedia, Sixth Edition, 2009
...physiological chemistry of the cell and its nucleus and of proteins, including nucleins. He discovered the purine adenine and the pyrimidine thymine. For this work he received the 1910 Nobel Prize in Physiology or Medicine. He wrote Protamines and Histones (tr...
4.
Cytosine
Encyclopedia article; The Columbia Encyclopedia, Sixth Edition, 2009
CYTOSINE si tosen , organic base of the pyrimidine family. It was isolated from the nucleic acid of calf thymus tissue in 1894. A suggested structure for cytosine, published in...
5.
Metabolite
Encyclopedia article; The Columbia Encyclopedia, Sixth Edition, 2009
...is used to prevent the rejection of transplanted organs. Pyrimidine antagonists used in cancer chemotherapy include fluorouracil...cells by the disruption of the metabolism of purines and pyrimidines, two classes of compounds necessary for nucleic acid synthesis...
More encyclopedia Results: 1-8 >>

Top...
 About Questia   ::   Privacy   ::   Contact