RESERPINE

rĕsûrˈpēn, alkaloid isolated from the root of the snakeroot plant (Rauwolfia serpentina), a small evergreen climbing shrub of the dogbane family native to the Indian subcontinent. Known in India as Sarpaganda, it was used for centuries to treat insanity as well as physical illnesses such as fevers and snakebites. After its isolation in 1952 it was used to lower high blood pressure, but its property of producing severe depression as a side effect also made it useful in psychiatry as a tranquilizer in the control of agitated psychotic patients. It has largely been replaced in psychiatric use by the phenothiazine tranquilizers, although it is still used as an experimental tool in the study of psychosis. Reserpine causes many toxic side effects including nightmares, Parkinsonism (see Parkinson's disease), and gastrointestinal disturbances.

____________________

The Columbia Encyclopedia, Sixth Edition Copyright© 2004, Columbia University Press. Licensed from Lernout & Hauspie Speech Products N.V. All rights reserved.

-40180-

Top...
Search the Library
Books
Journals
Magazines
Newspapers
Encyclopedia
Advanced Search
About Questia
Questia is the world's largest online academic library offering full-text books, journals, and articles on thousands of topics.

Join Now...
Questia Books and Articles on: Reserpine
We found: 277 results
By media type:
 

Books:

 

207  

 

Journal articles:

 

21  

 

Magazine articles:

 

41  

 

Newspaper articles:

 

3  

 

Encyclopedia articles:

 

5  
 

books on: Reserpine  - 207 results

       More book Results: 1-10 11-20 21-30 31-40 41-50 >>  
 
1.
Let Them Eat Prozac: The Unhealthy Relationship between the Pharmaceutical Industry and Depression
Book by David Healy; New York University Press, 2004
Subjects: Depression, Mental--Chemotherapy, Fluoxetine, Psychotropic Drugs Industry, Serotonin Uptake Inhibitors
...laboratories had shown that reserpine also lowered norepinephrine...levels. Unaware that reserpine had been shown to be...Schildkraut made reserpines capacity to lower norepinephrine...depression, on the basis of reserpines ability to trigger suicide. The capacity of reserpine to cause suicide was...
2.
Drugs in Psychoanalysis and Psychotherapy
Book by Mortimer Ostow; Basic Books, 1962
Subjects: Psychoanalysis, Psychopharmacology, Psychotherapy
...used large amounts of it over a long period. RESERPINE In the earlier discussion of reserpine see p. 306 , I noted chemical, pharmacologic...principally tranquilizers. The molecule of reserpine is considerably larger, more complex, and...
3.
A Century of Psychiatry
Book by Hugh Freeman; Mosby, 1999
Subjects: Psychiatry--History, Psychiatry--Social Aspects
...trial in psychiatry, using reserpine in anxious depressive out...antidepressant efficacy. Reserpine is a neuroleptic, and most...surprising. Yet, the evidence of reserpines antidepressant efficacy vanished...antidepressant at this time. Reserpine was seen as a major tranquilliser...
4.
Handbook of Abnormal Psychology: An Experimental Approach
Book by H. J. Eysenck; Basic Books, 1961
Subjects: Psychology, Experimental, Psychology, Pathological
tranquillizers such as reserpine are so much more enthusiastic than...2. Rauwolfia alkaloids of which reserpine Serpasil. Sandvil, Quiescin is the...appears to be more effective than reserpine, but it is not possible to predict...
5.
Human Fertility and Population Problems: Proceedings of the Seminar Sponsored by the American Academy of Arts and Sciences
Book by Roy O. Greep; Schenkman Pub. Co., 1963
Subjects: Birth Control--Congresses, Fertility, Human--Congresses, Population--Congresses
TABLE VI Effects of Reserpine Constant Dose on Ovulation in Intact...HCG Controls 5 5 58.0 8.2 125 g RESERPINE 54 hrs. before HCG 10 10 54.0 8...before HCG 6 6 56.2 9.3 data on reserpine given to intact superovulated immature...
More book Results: 1-10 11-20 21-30 31-40 41-50 >>

Top...
 

journal articles on: Reserpine  - 21 results

       More journal Results: 1-10 11-20 21-21 >>  
 
1.
Biochemical and Anatomical Substrates of Depression and Sickness Behavior
Journal article by Thomas C. Hanff, Stephanie J. Furst, Thomas R. Minor; The Israel Journal of Psychiatry and Related Sciences, Vol. 47, 2010
...and systemic injection of reserpine. We have examined the potential...injection of 6 mg/kg of reserpine. DA levels remained at floor...determined the time course for reserpines effect by injecting groups...single, 6 mg/kg, ip dose of reserpine or DMSO vehicle. Rats were...
2.
The New Anecdotes
Journal article by David Healy; Ethical Human Psychology and Psychiatry, Vol. 9, 2007
...controlled trials in medicine compared reserpine and placebo in a group of anxious depressives...Shepherd, 1955). The results showed reserpine to be effective in this population...Lancet, this RCT had almost no impact. Reserpine instead developed a reputation for causing...
3.
The Role of Transgenic Mouse Models in Carcinogen Identification
Journal article by John B. Pritchard, John E. French, Barbara J. Davis, Joseph K. Haseman; Environmental Health Perspectives, Vol. 111, 2003
...listed Pyridine 110-86-1 3 Not listed Reserpine 50-55-5 3 Reasonable Rotenone 83...Pyridine +; + or -; +w (NTP 2000) Reserpine +; -: +; +f (NCI/NTP 1982b) Rotenone...Methylphenidate -; NT Pyridine -; - Reserpine -; - Rotenone -; NT Resorcinol...
4.
Animal Models of Psychiatric Disorders and Their Relevance to Alcoholism
Journal article by Robert Hitzemann; Alcohol Research & Health, Vol. 24, 2000
...patients taking the antihypertension drug reserpine develop some symptoms of depression. In animals, reserpine causes locomotor depression. The observation...Transition Elevated Plus Maze Depression Reserpine- Induced Behaviors Learned Helplessness...
5.
Drosophila Vesicular Monoamine Transporter Mutants Can Adapt to Reduced or Eliminated Vesicular Stores of Dopamine and Serotonin
Journal article by Anne F. Simon, Richard Daniels, Rafael Romero-Calderón, Anna Grygoruk, Hui-Yun Chang, Rod Najibi, David Shamouelian, Evelyn Salazar, Mordecai Solomon, Larry C. Ackerson, Nigel T. Maidment, Aaron Diantonio, David E. Krantz; Genetics, Vol. 181, 2009
Subjects: Adults, Behavior, Drug abuse, Environmental health, Genetics, Grants, Neurological disorders
...in some cases lethal effects of acute DVMAT inhibition with reserpine (Pendleton et al. 1996, 2000; Chang et al. 2006), suggesting...homozygous and heterozygous mutants. In contrast to treatment with reserpine, which decreases motor activity (Pendleton et al. 2000...
More journal Results: 1-10 11-20 21-21 >>

Top...
 

magazine articles on: Reserpine  - 41 results

       More magazine Results: 1-10 11-20 21-30 31-40 41-41 >>  
 
1.
Science and the Resurrection
Magazine article by Michael A. Persinger; Skeptic, Vol. 9, 2002
Subjects: Death & dying, Epilepsy, Jesus Christ, New Testament, Theory
...consumption of plant extracts, like reserpine, and the subsequent but transient...on the sponge (if it were reserpine) would have produced severe...Considering the nature of reserpines influence, I suggest that...However, the effects of reserpine upon individuals whose brains...
2.
Tracking Aldicarb
Magazine article; FDA Consumer, Vol. 19, November 1985
Subjects: Aldicarb--Health aspects, Food poisoning--Investigations, Pesticides--Health aspects, United States. Food and Drug Administration--Investigations, Watermelons--Contamination
...The case is still pending. Elusive Reserpine For Marshall Pharmacal Corp., lot 8297 of bulk reserpine alkaloid tablets (25-milligram size...drugs, including one from lot 8297 of reserpine alkaloid, a prescription drug used to...
3.
Science and the Resurrection
Magazine article by Tobin Crenshaw, Jeremy Genovese, Bradley Bowen, Jerry Kahn; Skeptic, Vol. 10, 2003
Subjects: History, Miracles, Science
...temporal lobe" epileptic who was given "reserpine or a related drug" while he was "physically...with psychotropic traditions, such as reserpine and death-like conditions. This speculation...shred of evidence to suggest there was reserpine on the sponge. And why would Jesus take...
4.
Drug Product Selection and the Orange Book
Magazine article by John P. Bentley, Kent H. Summers; Drug Topics, 1994
Subjects: Continuing education, Generic drugs, Pharmacists, Professional practice, Selection, Substitution, United States
...capsule, tablet, Chlorothiazide with reserpine (tablets) and buccal) Chlorpheniramine...tablets) Hydralazine, hydrochlorthizide, and reserpine (tablets) Hydrochlorothizide with reserpine (tablets) Hydrochlorothizide with triamterene...
5.
Clinical Q&a: What Medications Should Be Avoided in the Elderly?
Magazine article by Joseph P. Nathan, Lorraine A. Cicero, Horatio Fung, Jack M. Rosenberg; Drug Topics, Vol. 143, April 19, 1999
Subjects: Older people, Prescription drugs, Problems, Side effects, United States
...should, therefore, be avoided. Methyldopa: This drug may cause bradycardia and exacerbate depression. Reserpine: In the elderly, reserpine imposes unnecessary risk of depression, impotence, sedation, and orthostatic hypotension. Ticlopidine...
More magazine Results: 1-10 11-20 21-30 31-40 41-41 >>

Top...
 

newspaper articles on: Reserpine  - 3 results

 
 
1.
OConnor: From Golden Glory to Shame in Weeks; Wearing the Laurels: Cian OConnor
Newspaper article; The Daily Mail (London, England), August 22, 2008
...be out of the horses system before he competed. But substances named a s zuclopenthixol, fluphenazine, guan-abenz and reserpine anti-psychotic drugs used in humans to treat severe anxiety, agitation and schizophrenia or to lower blood pressure were...
2.
A Mystery Plague Threatens to Wipe out the Worlds Bees. Just a Minor Threat to Your Breakfast Honey? Far from It. as a Chilling Newbookwarns, If the Bee Dies So Could We
Newspaper article; The Daily Mail (London, England), July 3, 2008
Subjects: Flowers, Honey, Honeybee
...treatsirregularitiesinheartrhythm,comes directly from foxglove flowers; the decongestantephedrineisfrom the shrub ephedra; and reserpine, whichlowers blood pressure, is made from serpent root. Chemicalsarealsoextracted from plants and used as buildingblockstocreatenewcompounds...
3.
The Mag: Health: Dr FORSTER Can Old Remedies Be Best Medicine? Dr George Forster Answers Your Questions
Newspaper article; Sunday Mercury (Birmingham, England), July 11, 2004
...Around 300 years ago a plant called snake root was used as a tranquilliser in south Asia. It contains a compound called reserpine, which is now used in the treatment of insomnia, schizophrenia, high blood pressure and even nervous disorders. During...


Top...
 

encyclopedia articles on: Reserpine  - 5 results

 
 
1.
Reserpine
Encyclopedia article; The Columbia Encyclopedia, Sixth Edition, 2009
RESERPINE resur pen, alkaloid isolated from the root of the snakeroot plant ( Rauwolfia...although it is still used as an experimental tool in the study of psychosis. Reserpine causes many toxic side effects including nightmares, Parkinsonism (see...
2.
Psychopharmacology
Encyclopedia article; The Columbia Encyclopedia, Sixth Edition, 2009
...depression ) and schizophrenia . The first drug of this type was reserpine , whose use dates from ancient Hindu medicine but whose reintroduction...antipsychotic drugs. Because of side effects, including depression, reserpine has been supplanted by phenothiazine drugs. The phenothiazine...
3.
Tranquilizer
Encyclopedia article; The Columbia Encyclopedia, Sixth Edition, 2009
...lower portions, e.g., the hypothalamus . They have been found helpful in the treatment of tension and mental illness. Reserpine , which appeared on the market in 1952, was the first tranquilizer to be used in modern Western medicine. Other drugs used...
4.
Alkaloid
Encyclopedia article; The Columbia Encyclopedia, Sixth Edition, 2009
...Aconitine is the alkaloid of aconite . Cinchonine and quinine are derived from cinchona , coniine is found in poison hemlock , and reserpine is an extract of rauwolfia roots. Emetine is an alkaloid of ipecac . ____________________ Copyright 2009...
5.
Woodward, Robert Burns
Encyclopedia article; The Columbia Encyclopedia, Sixth Edition, 2009
...1944), patulin (1950), cholesterol (1951), cortisone (1951), strychnine, lysergic acid, lanosterol (1954), reserpine (1956), chlorophyll (1960), and tetracycline (1962). For this work in organic synthesis he was awarded the 1965 Nobel...


Top...
 About Questia   ::   Privacy   ::   Contact