Current Psychiatry

Articles from Vol. 8, No. 3, March

Clozapine Drug Levels Guide Dosing
Finding the best clozapine dosage for your psychotic patient can be challenging because any given dose of the drug yields highly variable clozapine serum levels. This interindividual variability reflects clozapine's complex metabolism. Obtaining...
Compulsive Bruxism: How to Protect Your Patients' Teeth: Screen for Destructive Oral Habits Tied to Anxiety Disorders and SSRIs
Oral habits such as bruxism--compulsive grinding or clenching of the teeth--can be a manifestation of obsessive-compulsive disorder (OCD) and other anxiety disorders. (1) Bruxism also may be a side effect of selective serotonin reuptake inhibitors...
Diabetes Screening: Which Patients, What Tests, and How Often?
Psychiatric patients--especially those with schizophrenia or taking atypical antipsychotics--are at risk for developing type 2 diabetes mellitus (T2DM) and prediabetes conditions. T2DM can be present for years without significant symptoms and even...
Don't Get off Track with Off-Label Prescribing?
We read with interest Dr. Henry Nasrallah's comments on the shared pathophysiology of several common psychiatric disorders and his thoughts on innovative approaches to pharmacotherapy ("Diagnosis 2.0: Are mental illnesses diseases, disorders, or syndromes?"...
Fib Romyalgia: Psychiatric Drugs Target CNS-Linked Symptoms
Patients with fibromyalgia are a heterogeneous group, yet many describe a common experience: seeing multiple physicians who seem unable or unwilling to provide a diagnosis or treat their symptoms. This situation may be changing with the recent FDA...
Is Darwin Still Relevant? Advanced Human Brain Breaks Evolutionary Rules
You may have noticed the buzz about Charles Darwin in the news: 2009 marks the 200th anniversary of his birth and the 150th anniversary of his monumental description of evolution in On the Origin of Species. Celebrations are scheduled around the world...
'Night Owls': Reset the Physiologic Clock in Delayed Sleep Phase Disorder: Therapies Can Help Adjust Inherent 'Eveningness' in Drowsy Young Patients
Jason, age 16, has had difficulty with sleep initiation for 2 years. He describes going to bed at 10:30 PM on school nights but falling asleep no sooner than midnight and typically after 1:30 AM. He denies contributions from an "active mind" or environmental...
The Treatment-Resistant Catatonia Patient: Ms. R Develops Severe Catatonia after Being Hospitalized with Agitation, Delusions, and Hallucinations. A Benzodiazepine Does Not Help. How Would You Treat Her?
CASE Worsening psychosis Ms. R, age 21, is admitted to our psychiatric facility while experiencing paranoid delusions and auditory hallucinations. Upon admission, she is agitated and her mood is labile. Ms. R has 4 previous brief psychiatric...