Certain prenatal and maternal factors may be associated with attempted or completed suicide in offspring, according to Ellenor Mittendorfer-Rutz and her colleagues at the Karolinska Institute, Stockholm.
In a large cohort study involving more than 713,000 young adults born in Sweden between 1973 and 1980 and followed through 1999, a total of 563 committed suicide, and 6.676 attempted suicide. A significantly increased risk for attempted suicide was found in those with gestational age--adjusted short birth length, defined as length between 39 and 47 cm (hazard ratio 1.29), as well as in those born fourth or later in birth order (hazard ratio 1.79).
They also found this increased risk in those born to mothers with a low educational level, defined as fewer than 9 years of education (hazard ratio 1.36), and in those born to a teenage mother (hazard ratio 2.09).
Significant predictors of completed suicide included gestational age-adjusted low birth weight, defined as birth weight below 2,500 g (hazard ratio 2.23) and being born to a teenage mother (hazard ratio 2.30), the investigators found (Lancet 2004;364:1135-40).
They acknowledged that the study is limited by the fact that some patient registers exclude those who were not admitted after a suicide attempt, and by the upper patient age of 26 in this study, which suggests the findings may not apply to older individuals. …