PTSD Research Targets Memory Reconsolidation: Treatment, Which Usually Involves Propranolol, Erases Emotional Reaction to the Traumatic Memory

Article excerpt

MONTREAL - The field of psychiatry is facing a shift, with new research suggesting that medications and psychotherapy might be able to permanently erase the "trauma" from traumatic memories, several experts say.

The experimental treatment, known as reconsolidation blockade, has been shown to interrupt the neurobiologic process of memory formation.

"We do not erase people's memories," Alain Brunet, Ph.D., said at the meeting. Dr. Brunet of the department of psychiatry at McGill University, Montreal, is one of the first researchers to report results of the treatment in patients with posttraumatic stress disorder (PTSD).

Rather than erasing an entire memory, reconsolidation blockade appears to erase the emotional reaction to the memory, explained Dr. Roger K. Pitman, director of the posttraumatic stress disorder and psychophysiology laboratory at Massachusetts General Hospital and professor of psychiatry at Harvard Medical School, both in Boston.

The treatment, which normally involves two doses of the beta-blocker propranolol administered between 75 minutes and 2 hours apart, is "pioneering" in that it upends traditional theories about the permanence of memory, said Dr. Charles Marmar, professor and chair of the department of psychiatry and director of the Trauma Research Group at New York University.

Traditional cognitive-behavioral treatment for PTSD is based on the premise that traumatic memory is permanent, and therefore therapy should focus on learning a less emotional response to it, explained Gregory Quirk, Ph.D., professor of psychiatry and director of the laboratory of fear learning at the University of Puerto Rico, San Juan.

This learned response, known as "extinction," changes the body's physiologic, amygdala-based memory, and teaches a cognitive, hippocampal response to the memory instead, he said. "With extinction, you reroute the stimulus so it does not go to the amygdala. You're teaching the brain - it's a learned thing - but the original memory is still in the amygdala somewhere. Extinction does not alter the original memory - we know that from Pavlov." Extinction works well in certain psychiatric conditions, such as phobia, but people with PTSD have hippocampal and prefrontal deficits that frequently cause extinction failure, he said.

In contrast, reconsolidation blockade does not recruit the hippocampus but instead targets the amygdala-dependent reaction. "I am very excited about reconsolidation blockade," Dr. Quirk said. "What's new and exciting about this shift is that you don't have to struggle your whole life with these terrible memories. You can alter them instead."

The theory behind reconsolidation blockade is that after a traumatic memory is consolidated in the brain, it can be reactivated and exist in a labile, modifiable state. During the labile window, which is believed to last up to 6 hours, propranolol can block protein synthesis involved in amygdala-dependent reconsolidation. "There's no loss of the hippocampal-dependent declarative memory--what's lost is the amygdala-dependent reaction that makes patients sick," Dr. Quirk said. "And that's exactly the thing we want to erase - the part of the memory that makes them ill."

In one study conducted by Dr. Pitman and Dr. Brunet, PTSD patients treated with propranolol after memory reactivation showed a significantly decreased physiologic response when they engaged in script-driven mental imagery of their traumatic event 1 week later, compared with placebo-treated patients (J. …