In the Lab; Seeking Therapeutic Strategies for Type 1 Diabetes

Article excerpt

Following is a list of some of the medical research grants awarded to scientists in the area.

WASHINGTON UNIVERSITY SCHOOL OF MEDICINE

The scientist * Garland Marshall, Ph.D., professor of biochemistry and molecular biophysics and of biomedical engineering, collaborating with Lee Ratner, M.D., Ph.D., professor of medicine and of molecular microbiology and Jay Ponder, Ph.D., associate professor of chemistry.

The grant * $1.4 million from the National Institute of General Medical Sciences.

The study * Discovery of new therapeutics for drug-free remission of HIV.

The scientist * Melissa Swiecki, Ph.D., research instructor of pathology and immunology.

The grant * $426,090 from the National Institutes of Health.

The study * Looking to better understand the nature and function of cell types involved in promoting or curbing Type 1 diabetes pathogenesis. It is hoped this can lead to better treatment and therapeutic strategies that may ease financial burden and improve quality of life. Type 1 diabetes is one of the most common chronic diseases in children and young adolescents.

The scientist * Marco Colonna, M.D., professor of pathology and immunology and of medicine.

The grant * $418,000 from the National Institutes of Health.

The study * Looking at the role of Il-34 in the biology of Langerhans cells. IL-34 is a protein produced by cells of the epidermis that sustains the survival of Langerhans cells. Langerhans cells are sentinel cells of the skin that initiate immune responses to UV light, allergens and infectious agents.

The scientist * Kristen Kroll, Ph.D., associate professor, Department of Developmental Biology.

The grant * $417,518 from the March of Dimes.

The study * Looking at a common birth defect of the nervous system called neural tube defects and trying to understand what commonly goes wrong at the molecular level which may enable earlier diagnosis.

The scientist * Clarissa S. Craft, Ph.D., research assistant professor of cell biology and physiology.

The grant * $400,200 from the American Diabetes Association.

The study * Looking at how the extracellular matrix (a milieu of molecules that organizes individual cells into a function tissue) regulates the progression of metabolic diseases like obesity and diabetes, thereby identifying new targets for therapy.

The scientist * Bradley Freeman, M.D., professor in the Division of General Surgery, Acute and Critical Care Surgery Section.

The grant * $393,205 from the U.S. Army Medical Research Acquisition Act.

The study * Early ICU standardized rehabilitation therapy for the critically injured burn patient.

The scientist * Nabeel Yaseen, M.D., Ph.D., associate professor of pathology and immunology. …