Memory Consolidation: Psychobiology of Cognition

By Herbert Weingartner; Elizabeth S. Parker | Go to book overview
Save to active project

3 Endogenous Processes in Memory Consolidation

Paul E. Gold University of Virginia

James L. McGaugh Center for the Neurobiology of Learning and Memory and Department of Psychobiology University of California, Irvine


Until relatively recently, the evidence that the brain is changed by experience was based solely on indirect behavioral assessments of changes: Training can produce long-lasting changes in behavior; therefore, the brain must, it would seem, be changed by experience. There is now abundant evidence that change does occur. One of the recent major advances in neurobiology is an ever-expanding list of long-term changes in brain structure and function elicited by training procedures and neural manipulation. Early demonstrations that animals raised in enriched or impoverished conditions differ in brain weight ( Rosenzweig & Bennett, 1978) were followed by anatomical evidence of precise remodeling of synaptic terminations following brain damage ( Lynch & Wells, 1978; Steward, 1982), as well as evidence of changes in dendritic branching patterns produced by differential experiences ( Floeter & Greenough, 1979; Juraska, Greenough, Elliot, Mack, & Berkowitz, 1980). Neurophysiological changes induced by stimulation include altered cell firing rates during conditioning ( Oleson, Ashe, & Weinberger, 1975; McCormick, Clark, Lavond, & Thompson, 1982), as well as long-lasting changes produced by electrical stimulation of certain brain areas, such as long-term potentiation ( Lynch, Browning, & Bennett, 1979; Goddard, 1980), and kindling ( Racine, 1978; McNamara, Byrne, Dashieff, & Fitz, 1980). Finally, biochemical studies have revealed changes in neurotransmitter receptor sensitivity under a variety of experimental and endogenous conditions ( Reisine, 1981) and long-term induction of transmitter-related enzyme activity and syn


Notes for this page

Add a new note
If you are trying to select text to create highlights or citations, remember that you must now click or tap on the first word, and then click or tap on the last word.
Loading One moment ...
Project items
Cite this page

Cited page

Citations are available only to our active members.
Sign up now to cite pages or passages in MLA, APA and Chicago citation styles.

Cited page

Bookmark this page
Memory Consolidation: Psychobiology of Cognition


Text size Smaller Larger
Search within

Search within this book

Look up

Look up a word

  • Dictionary
  • Thesaurus
Please submit a word or phrase above.
Print this page

Print this page

Why can't I print more than one page at a time?

While we understand printed pages are helpful to our users, this limitation is necessary to help protect our publishers' copyrighted material and prevent its unlawful distribution. We are sorry for any inconvenience.
Full screen
/ 278

matching results for page

Cited passage

Citations are available only to our active members.
Sign up now to cite pages or passages in MLA, APA and Chicago citation styles.

Cited passage

Welcome to the new Questia Reader

The Questia Reader has been updated to provide you with an even better online reading experience.  It is now 100% Responsive, which means you can read our books and articles on any sized device you wish.  All of your favorite tools like notes, highlights, and citations are still here, but the way you select text has been updated to be easier to use, especially on touchscreen devices.  Here's how:

1. Click or tap the first word you want to select.
2. Click or tap the last word you want to select.

OK, got it!

Thanks for trying Questia!

Please continue trying out our research tools, but please note, full functionality is available only to our active members.

Your work will be lost once you leave this Web page.

For full access in an ad-free environment, sign up now for a FREE, 1-day trial.

Already a member? Log in now.

Are you sure you want to delete this highlight?