beta-blocker

The Columbia Encyclopedia, 6th ed.

beta-blocker

beta-blocker or beta-adrenergic blocking agent (bā´tə ăd´rənûr´jĬk), drug that reduces the symptoms connected with hypertension, cardiac arrhythmias, angina pectoris, migraine headaches, and other disorders related to the sympathetic nervous system. Beta-blockers also are sometimes given after heart attacks to stabilize the heartbeat. Within the sympathetic nervous system, beta-adrenergic receptors are located mainly in the heart, lungs, kidneys, and blood vessels. Beta-blockers compete with the nerve-stimulating hormone epinephrine for these receptor sites and thus interfere with the action of epinephrine, lowering blood pressure and heart rate, stopping arrhythmias, and preventing migraine headaches. Because it is also epinephrine that prepares the body for "fight or flight" in stressful or fearful situations, beta-blockers are sometimes used as antianxiety drugs, especially for stage fright and the like. People taking a beta-blocker must avoid caffeine, alcohol, and salty foods, because the interaction of those substances and the drug can raise the heart rate and blood pressure. Propranolol (Inderal) is a commonly used beta-blocker.

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