Paraoxonase (PON1) in Health and Disease: Basic and Clinical Aspects

By McQueen, Charlene A. | Environmental Health Perspectives, August 15, 2003 | Go to article overview

Paraoxonase (PON1) in Health and Disease: Basic and Clinical Aspects


McQueen, Charlene A., Environmental Health Perspectives


Edited by Lucio G. Costa and Clement E. Furlong Boston, MA: Kluwer Academic, 2002. 216 pp. ISBN: 1-4020-7282-1, $95 cloth.

Paraoxonase (PON1) in Health and Disease: Basic and Clinical Aspects is a complete and timely review of the biochemistry, genetics, and toxicology of the enzyme paraoxonase. The 10 chapters in the volume provide a comprehensive summary of the current knowledge concerning PON1. The history of the discovery and the biochemical characterization of the enzyme set the stage for the subsequent discussion of the genetic polymorphisms, role in lipid metabolism, atherosclerosis and disease, species variation, and organophosphate toxicity.

The discovery of this genetic polymorphism predated the Human Genome Project and illustrates how pharmacogenetics had to be done in the pregenomic era. The story of PON1 begins with the identification of an enzyme having organophosphates as substrates. Reports of the geographic differences in population frequencies of paraoxonase activity and genetic analysis led to uncovering the genetic polymorphism. At the time, the ramifications of the polymorphism seemed to be limited to populations exposed to a relatively discrete group of xenobiotics. But that was only the beginning, as astute observations led to uncovering a physiologic mechanism through which PON1 protects against oxidative damage of low-density lipoproteins. Subsequently, PON1 has been shown to be a risk factor for coronary artery disease. There are also data implicating PON1 in other diseases and in Gulf War Syndrome, although more research is needed is these areas. This scientific history of PON1 is an excellent example of how genetics, toxicology, biochemistry, and physiology work in concert to understand the basis of human health.

The rest of this article is only available to active members of Questia

Sign up now for a free, 1-day trial and receive full access to:

  • Questia's entire collection
  • Automatic bibliography creation
  • More helpful research tools like notes, citations, and highlights
  • Ad-free environment

Already a member? Log in now.

Notes for this article

Add a new note
If you are trying to select text to create highlights or citations, remember that you must now click or tap on the first word, and then click or tap on the last word.
One moment ...
Project items

Items saved from this article

This article has been saved
Highlights (0)
Some of your highlights are legacy items.

Highlights saved before July 30, 2012 will not be displayed on their respective source pages.

You can easily re-create the highlights by opening the book page or article, selecting the text, and clicking “Highlight.”

Citations (0)
Some of your citations are legacy items.

Any citation created before July 30, 2012 will labeled as a “Cited page.” New citations will be saved as cited passages, pages or articles.

We also added the ability to view new citations from your projects or the book or article where you created them.

Notes (0)
Bookmarks (0)

You have no saved items from this article

Project items include:
  • Saved book/article
  • Highlights
  • Quotes/citations
  • Notes
  • Bookmarks
Notes
Cite this article

Cited article

Style
Citations are available only to our active members.
Sign up now to cite pages or passages in MLA, APA and Chicago citation styles.

(Einhorn, 1992, p. 25)

(Einhorn 25)

1

1. Lois J. Einhorn, Abraham Lincoln, the Orator: Penetrating the Lincoln Legend (Westport, CT: Greenwood Press, 1992), 25, http://www.questia.com/read/27419298.

Cited article

Paraoxonase (PON1) in Health and Disease: Basic and Clinical Aspects
Settings

Settings

Typeface
Text size Smaller Larger
Search within

Search within this article

Look up

Look up a word

  • Dictionary
  • Thesaurus
Please submit a word or phrase above.
Print this page

Print this page

Why can't I print more than one page at a time?

Full screen

matching results for page

Cited passage

Style
Citations are available only to our active members.
Sign up now to cite pages or passages in MLA, APA and Chicago citation styles.

"Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences." (Einhorn, 1992, p. 25).

"Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences." (Einhorn 25)

"Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences."1

1. Lois J. Einhorn, Abraham Lincoln, the Orator: Penetrating the Lincoln Legend (Westport, CT: Greenwood Press, 1992), 25, http://www.questia.com/read/27419298.

Cited passage

Welcome to the new Questia Reader

The Questia Reader has been updated to provide you with an even better online reading experience.  It is now 100% Responsive, which means you can read our books and articles on any sized device you wish.  All of your favorite tools like notes, highlights, and citations are still here, but the way you select text has been updated to be easier to use, especially on touchscreen devices.  Here's how:

1. Click or tap the first word you want to select.
2. Click or tap the last word you want to select.

OK, got it!

Thanks for trying Questia!

Please continue trying out our research tools, but please note, full functionality is available only to our active members.

Your work will be lost once you leave this Web page.

For full access in an ad-free environment, sign up now for a FREE, 1-day trial.

Already a member? Log in now.