The Flab Dissolver; New Drug Is 'Liposuction without Surgery' Say Experts after Trials Show It Can Reduce Body Weight by a Third

Daily Mail (London), May 10, 2004 | Go to article overview

The Flab Dissolver; New Drug Is 'Liposuction without Surgery' Say Experts after Trials Show It Can Reduce Body Weight by a Third


Byline: TIM UTTON

A DRUG which 'melts away' fat could revolutionise the fight against obesity, scientists claimed yesterday.

Its effect has been likened to ' liposuction inside the body' - but without expensive and invasive surgery.

Research published last night shows that the drug prompted weight loss of 30 per cent in four weeks, with no apparent ill effects.

It destroys the blood supply to fat tissue, causing the fat to break down, effectively dissolving it.

Doctors and Government experts have warned of an obesity timebomb threatening the health of the nation.

One in five UK adults is now classed as clinically obese.

The drug being pioneered in the U.S. could be on the market by the end of the decade. By then, the need for it will be still greater - on current trends a third of British adults will be obese.

Most current treatments are aimed at stopping weight gain. Many work by suppressing appetite, or 'tricking' the body into feeling full.

But researchers say their drug promises to open up a new front.

Dr Mikhail Kolonin, of the University of Texas, said: 'Our approach is unique because it shows in animal models that we can remove alreadyformed fat by a non- surgical method, a molecular liposuction.' Co-researcher, Professor Renata Pasqualini, said: 'We are cautiously optimistic that there may be a new way to think about reversing obesity.' The drug was tested on mice who were fed a high calorie diet until they doubled in weight.

They were then given the drug and over four weeks lost almost a third of their total body weight.

The team, whose research was published in the journal Nature Medicine, is about to start trials in monkeys as the next step towards human trials.

Their drug does not target fat cells directly, but instead attacks the tiny blood vessels that supply them. …

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The Flab Dissolver; New Drug Is 'Liposuction without Surgery' Say Experts after Trials Show It Can Reduce Body Weight by a Third
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