Keeping Human Tissue Transplants Safe

By Bren, Linda | FDA Consumer, May-June 2005 | Go to article overview

Keeping Human Tissue Transplants Safe


Bren, Linda, FDA Consumer


When the surgeon put in a special request for an elbow, Donor Alliance of Denver started searching immediately. The elbow bone and surrounding cartilage had to fit specific dimensions and be from the right arm of a female donor of a certain age. A match was found, and the surgeon transplanted the live joint tissue into 18-year-old Nikki Fix.

Fix had fought leukemia with drugs that saved her life but that had a painful and debilitating side effect. "My joints started to collapse," says the Eaton, Colo., resident, who received her new elbow in September 2004. It wasn't the first such surgery for Fix. The year before, she got a new knee joint from another donor.

"I have a few limitations," says Fix. "I'm not supposed to run or jump, and I have to watch how much I'm lifting." But Fix considers herself fortunate. She is pain-free, has use of her arm again, and walks without limping. And her leukemia has been in remission for two years.

Fix is one of the many people who have benefited from tissue donations. The nation's tissue banks distributed more than 1 million tissue grafts in 2003, according to the American Association of Tissue Banks (AATB). Most tissues come from people who have chosen to donate their organs and tissues after death to help others live longer or to improve their quality of life.

"One donor can save eight lives through organ donation and enhance up to 50 through tissue donation," says Steve Mansfield, vice president of tissue banking operations at Donor Alliance, a nonprofit organization that helps procure organs and tissues, including Fix's elbow and knee.

Organ transplants are usually lifesaving and involve the replacement of whole organs--the kidneys, liver, heart, lungs, pancreas, or intestine. Tissue transplants also are used sometimes to save lives, says Mansfield, but most tissue transplants enhance the lives of recipients. Tissues that can be transplanted include bone, skin, corneas, tendons, ligaments, and heart valves.

Bone tissue can restore function to damaged joints, as in Fix's case. Or it can prevent limb amputation by replacing cancerous bone. A covering of donated skin may prevent infections in severely burned people until new skin can regrow. Donated corneal tissue, the outer coating of the eyeball, can restore sight to people with eye disease. And healthy leg veins can replace damaged arteries in people with poor circulation.

Donated heart-valve tissue can be a lifesaving gift for a person with a failing heart valve. And reproductive tissue, provided by living donors, can be a gift that allows an infertile couple to have children.

But like blood and other body fluids, these living materials can transmit disease. Concern over this potential has led the Food and Drug Administration to strengthen its oversight over the human tissue industry. And the tissue industry and state governments are working with the agency to safeguard patients who receive these life-enhancing and lifesaving tissues.

The Risk

"The overall risk of disease transmission through tissue transplantation is believed to be very low," says Jesse Goodman, M.D., M.P.H., director of the FDA's Center for Biologics Evaluation and Research. But in the rare incidents of disease transmission, the results have been tragic. In 2001, for example, a 23-year-old Minnesota man died four days after receiving a transplant of bone and cartilage to reconstruct his knee. He had acquired a deadly infection from toxic bacteria in the tissue. A delay in refrigerating the donor cadaver before the tissue was harvested was believed to have triggered the growth of the bacteria, according to the Centers for Disease Control and Prevention (CDC).

In 2002, five tissue recipients in the United States were believed to be infected by hepatitis C from a single donor's tissues. And in 2003, contaminated corneas resulted in infections and vision loss in two people. …

The rest of this article is only available to active members of Questia

Sign up now for a free, 1-day trial and receive full access to:

  • Questia's entire collection
  • Automatic bibliography creation
  • More helpful research tools like notes, citations, and highlights
  • Ad-free environment

Already a member? Log in now.

Notes for this article

Add a new note
If you are trying to select text to create highlights or citations, remember that you must now click or tap on the first word, and then click or tap on the last word.
One moment ...
Default project is now your active project.
Project items

Items saved from this article

This article has been saved
Highlights (0)
Some of your highlights are legacy items.

Highlights saved before July 30, 2012 will not be displayed on their respective source pages.

You can easily re-create the highlights by opening the book page or article, selecting the text, and clicking “Highlight.”

Citations (0)
Some of your citations are legacy items.

Any citation created before July 30, 2012 will labeled as a “Cited page.” New citations will be saved as cited passages, pages or articles.

We also added the ability to view new citations from your projects or the book or article where you created them.

Notes (0)
Bookmarks (0)

You have no saved items from this article

Project items include:
  • Saved book/article
  • Highlights
  • Quotes/citations
  • Notes
  • Bookmarks
Notes
Cite this article

Cited article

Style
Citations are available only to our active members.
Sign up now to cite pages or passages in MLA, APA and Chicago citation styles.

(Einhorn, 1992, p. 25)

(Einhorn 25)

1

1. Lois J. Einhorn, Abraham Lincoln, the Orator: Penetrating the Lincoln Legend (Westport, CT: Greenwood Press, 1992), 25, http://www.questia.com/read/27419298.

Cited article

Keeping Human Tissue Transplants Safe
Settings

Settings

Typeface
Text size Smaller Larger Reset View mode
Search within

Search within this article

Look up

Look up a word

  • Dictionary
  • Thesaurus
Please submit a word or phrase above.
Print this page

Print this page

Why can't I print more than one page at a time?

Full screen

matching results for page

Cited passage

Style
Citations are available only to our active members.
Sign up now to cite pages or passages in MLA, APA and Chicago citation styles.

"Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences." (Einhorn, 1992, p. 25).

"Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences." (Einhorn 25)

"Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences."1

1. Lois J. Einhorn, Abraham Lincoln, the Orator: Penetrating the Lincoln Legend (Westport, CT: Greenwood Press, 1992), 25, http://www.questia.com/read/27419298.

Cited passage

Welcome to the new Questia Reader

The Questia Reader has been updated to provide you with an even better online reading experience.  It is now 100% Responsive, which means you can read our books and articles on any sized device you wish.  All of your favorite tools like notes, highlights, and citations are still here, but the way you select text has been updated to be easier to use, especially on touchscreen devices.  Here's how:

1. Click or tap the first word you want to select.
2. Click or tap the last word you want to select.

OK, got it!

Thanks for trying Questia!

Please continue trying out our research tools, but please note, full functionality is available only to our active members.

Your work will be lost once you leave this Web page.

For full access in an ad-free environment, sign up now for a FREE, 1-day trial.

Already a member? Log in now.