Statin Use May Improve Poststroke Mortality

By Evans, Jeff | Clinical Psychiatry News, March 2008 | Go to article overview

Statin Use May Improve Poststroke Mortality


Evans, Jeff, Clinical Psychiatry News


Patients who discontinue their use of statins within the first year after a stroke may have a significantly increased risk of death, even in the absence of diagnosed heart disease, according to findings from a single-center observational study.

"This is the first evidence linking discontinuation of statins to increased mortality in stroke survivors without any clinical evidence of CHD," reported Dr. Furio Colivicchi of the San Filippo Neri Hospital, Rome, and his colleagues.

"The findings suggest that patient care should be improved during the transition from a hospital setting to outpatient primary care."

From a consecutive series of 3,974 patients with acute stroke who were discharged from a hospital during a 4.5-year period, the researchers selected 631 patients who had no major concurrent illness, no evidence of coronary artery disease or other major cardiac conditions, and who were discharged on either atorvastatin (Lipitor) or simvastatin (Zocor) to determine what effect statin discontinuation had on mortality during the first year after stroke.

The 631 patients in the study had an average age of 70 years (Stroke 2007 [Epub doi:10.1161/strokeaha.107.487017]).

In multivariate analysis, discontinuation of statins was an independent predictor of all-cause mortality at 1 year; patients who discontinued statins had nearly a threefold higher risk of death than those who continued to take their prescription. The risk of death was highest soon after discontinuing statins and gradually decreased with time.

Of 246 patients who discontinued statin therapy during the 1-year follow-up period, 175 (71%) had no specific medical reason for discontinuation. Mild side effects, such as dyspepsia, fatigue, headache, myalgias, and an asymptomatic rise in plasma levels of liver enzymes, were the reason for discontinuation in the remaining 71 (29%) patients.

The rest of this article is only available to active members of Questia

Sign up now for a free, 1-day trial and receive full access to:

  • Questia's entire collection
  • Automatic bibliography creation
  • More helpful research tools like notes, citations, and highlights
  • Ad-free environment

Already a member? Log in now.

Notes for this article

Add a new note
If you are trying to select text to create highlights or citations, remember that you must now click or tap on the first word, and then click or tap on the last word.
One moment ...
Project items

Items saved from this article

This article has been saved
Highlights (0)
Some of your highlights are legacy items.

Highlights saved before July 30, 2012 will not be displayed on their respective source pages.

You can easily re-create the highlights by opening the book page or article, selecting the text, and clicking “Highlight.”

Citations (0)
Some of your citations are legacy items.

Any citation created before July 30, 2012 will labeled as a “Cited page.” New citations will be saved as cited passages, pages or articles.

We also added the ability to view new citations from your projects or the book or article where you created them.

Notes (0)
Bookmarks (0)

You have no saved items from this article

Project items include:
  • Saved book/article
  • Highlights
  • Quotes/citations
  • Notes
  • Bookmarks
Notes
Cite this article

Cited article

Style
Citations are available only to our active members.
Sign up now to cite pages or passages in MLA, APA and Chicago citation styles.

(Einhorn, 1992, p. 25)

(Einhorn 25)

1

1. Lois J. Einhorn, Abraham Lincoln, the Orator: Penetrating the Lincoln Legend (Westport, CT: Greenwood Press, 1992), 25, http://www.questia.com/read/27419298.

Cited article

Statin Use May Improve Poststroke Mortality
Settings

Settings

Typeface
Text size Smaller Larger
Search within

Search within this article

Look up

Look up a word

  • Dictionary
  • Thesaurus
Please submit a word or phrase above.
Print this page

Print this page

Why can't I print more than one page at a time?

Full screen

matching results for page

Cited passage

Style
Citations are available only to our active members.
Sign up now to cite pages or passages in MLA, APA and Chicago citation styles.

"Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences." (Einhorn, 1992, p. 25).

"Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences." (Einhorn 25)

"Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences."1

1. Lois J. Einhorn, Abraham Lincoln, the Orator: Penetrating the Lincoln Legend (Westport, CT: Greenwood Press, 1992), 25, http://www.questia.com/read/27419298.

Cited passage

Welcome to the new Questia Reader

The Questia Reader has been updated to provide you with an even better online reading experience.  It is now 100% Responsive, which means you can read our books and articles on any sized device you wish.  All of your favorite tools like notes, highlights, and citations are still here, but the way you select text has been updated to be easier to use, especially on touchscreen devices.  Here's how:

1. Click or tap the first word you want to select.
2. Click or tap the last word you want to select.

OK, got it!

Thanks for trying Questia!

Please continue trying out our research tools, but please note, full functionality is available only to our active members.

Your work will be lost once you leave this Web page.

For full access in an ad-free environment, sign up now for a FREE, 1-day trial.

Already a member? Log in now.