Risk of Colorectal Adenoma Is Up in Smokers

By Kirn, Timothy F. | Clinical Psychiatry News, March 2008 | Go to article overview
Save to active project

Risk of Colorectal Adenoma Is Up in Smokers


Kirn, Timothy F., Clinical Psychiatry News


Cigarette smoking does appear to be linked to a higher risk of colorectal adenoma, to a large enough degree that perhaps smoking history should be considered in guidelines for colonoscopy screening, Edoardo Botteri and colleagues reported.

The smoking-associated risk described in the report, a meta-analysis of 42 studies, indicates that a person who has smoked two packs per day for 25 years has almost twice the risk (relative risk, 1.88) of having a colorectal adenoma as a person who has never smoked, reported Mr. Botteri of the division of epidemiology and biostatistics at the European Institute of Oncology, Milan, and his colleagues.

The meta-analysis also indicated that the association between smoking and adenomatous polyps was stronger for high-risk adenomas than for low-risk adenomas. That finding contradicts some previous observations, made based on single studies, and suggests that smoking probably is associated with a higher risk of colon cancer. In the past, this question has been unresolved, the authors said (Gastroenterology 2008;134:388-95).

The investigators began by conducting a search of the PubMed database for relevant studies, and then scanned the references of the studies they reviewed to identify any studies they might have missed.

In total they identified 125 studies worthy of review, of which 42 were either independent case-control or nested case-control studies that met the criteria for inclusion in the meta-analysis. Twenty-six of those studies used colonoscopy or sigmoidoscopy plus barium enema and x-ray to view the entire colon. Sixteen studies used only sigmoidoscopy and did not view the entire colon.

After they pooled the data from the studies, the investigators found that current smokers had a relative risk for colorectal adenoma of 2.14, compared with never smokers. The pooled estimate for former smokers versus never smokers was a relative risk of 1.47, and the pooled estimate for ever smokers versus never smokers was a relative risk of 1.82.

When the investigators analyzed the data from a dose-response point of view, assuming a linear increase in risk, they found a 13% increased risk of presenting with adenomatous polyps for every additional 10 pack-years smoked, relative to never smokers.

The rest of this article is only available to active members of Questia

Sign up now for a free, 1-day trial and receive full access to:

  • Questia's entire collection
  • Automatic bibliography creation
  • More helpful research tools like notes, citations, and highlights
  • Ad-free environment

Already a member? Log in now.

Notes for this article

Add a new note
If you are trying to select text to create highlights or citations, remember that you must now click or tap on the first word, and then click or tap on the last word.
Loading One moment ...
Project items
Notes
Cite this article

Cited article

Style
Citations are available only to our active members.
Sign up now to cite pages or passages in MLA, APA and Chicago citation styles.

Cited article

Risk of Colorectal Adenoma Is Up in Smokers
Settings

Settings

Typeface
Text size Smaller Larger
Search within

Search within this article

Look up

Look up a word

  • Dictionary
  • Thesaurus
Please submit a word or phrase above.
Print this page

Print this page

Why can't I print more than one page at a time?

While we understand printed pages are helpful to our users, this limitation is necessary to help protect our publishers' copyrighted material and prevent its unlawful distribution. We are sorry for any inconvenience.
Full screen

matching results for page

Cited passage

Style
Citations are available only to our active members.
Sign up now to cite pages or passages in MLA, APA and Chicago citation styles.

Cited passage

Welcome to the new Questia Reader

The Questia Reader has been updated to provide you with an even better online reading experience.  It is now 100% Responsive, which means you can read our books and articles on any sized device you wish.  All of your favorite tools like notes, highlights, and citations are still here, but the way you select text has been updated to be easier to use, especially on touchscreen devices.  Here's how:

1. Click or tap the first word you want to select.
2. Click or tap the last word you want to select.

OK, got it!

Thanks for trying Questia!

Please continue trying out our research tools, but please note, full functionality is available only to our active members.

Your work will be lost once you leave this Web page.

For full access in an ad-free environment, sign up now for a FREE, 1-day trial.

Already a member? Log in now.

Are you sure you want to delete this highlight?