Stem Cell Snag: Implanted Cells May Show Signs of Parkinson's

By Barry, Patrick | Science News, April 12, 2008 | Go to article overview

Stem Cell Snag: Implanted Cells May Show Signs of Parkinson's


Barry, Patrick, Science News


For the first time, researchers have found evidence that Parkinson's disease might spread to healthy nerve cells implanted into a patient's brain.

In postmortem studies, researchers found that a small minority of implanted cells in three patients had acquired traits associated with the disease. But for five other transplant recipients, the implanted neurons appeared healthy and functioning at the time of death, up to 16 years after surgery.

The finding could have implications for the use of stem cells to treat Parkinson's. These proposed therapies would implant healthy nerve cells into a patient's brain to replace cells damaged by the disease and partially relieve symptoms, mainly the poor control of body movement characteristic of Parkinson's. Doctors would derive new nerve cells from embryonic-like stem cells, rather than taking nerve cells from human fetuses, as was done for the patients in the new studies.

Healthy survival of most of the implanted neurons bodes well for the stem cell approach, comments stem cell-therapy researcher Viviane Tabar of the Memorial Sloan-Kettering Cancer Center in New York City. But scientists need to understand why some cells unexpectedly developed Parkinson's-like conditions, she says.

"This goes to prove how little we understand Parkinson's disease," Tabar says. "I'm not closing my lab and giving up on stem cell therapies for Parkinson's. It's just an opportunity to learn more about how to do these therapies correctly."

In a trio of studies published online April 6 in Nature Medicine, scientists in Sweden, England, Canada and the United States searched the brains of the transplant recipients for cells that contained dumps of the protein alpha-synuclein. …

The rest of this article is only available to active members of Questia

Sign up now for a free, 1-day trial and receive full access to:

  • Questia's entire collection
  • Automatic bibliography creation
  • More helpful research tools like notes, citations, and highlights
  • Ad-free environment

Already a member? Log in now.

Notes for this article

Add a new note
If you are trying to select text to create highlights or citations, remember that you must now click or tap on the first word, and then click or tap on the last word.
One moment ...
Default project is now your active project.
Project items

Items saved from this article

This article has been saved
Highlights (0)
Some of your highlights are legacy items.

Highlights saved before July 30, 2012 will not be displayed on their respective source pages.

You can easily re-create the highlights by opening the book page or article, selecting the text, and clicking “Highlight.”

Citations (0)
Some of your citations are legacy items.

Any citation created before July 30, 2012 will labeled as a “Cited page.” New citations will be saved as cited passages, pages or articles.

We also added the ability to view new citations from your projects or the book or article where you created them.

Notes (0)
Bookmarks (0)

You have no saved items from this article

Project items include:
  • Saved book/article
  • Highlights
  • Quotes/citations
  • Notes
  • Bookmarks
Notes
Cite this article

Cited article

Style
Citations are available only to our active members.
Sign up now to cite pages or passages in MLA, APA and Chicago citation styles.

(Einhorn, 1992, p. 25)

(Einhorn 25)

1

1. Lois J. Einhorn, Abraham Lincoln, the Orator: Penetrating the Lincoln Legend (Westport, CT: Greenwood Press, 1992), 25, http://www.questia.com/read/27419298.

Cited article

Stem Cell Snag: Implanted Cells May Show Signs of Parkinson's
Settings

Settings

Typeface
Text size Smaller Larger Reset View mode
Search within

Search within this article

Look up

Look up a word

  • Dictionary
  • Thesaurus
Please submit a word or phrase above.
Print this page

Print this page

Why can't I print more than one page at a time?

Full screen

matching results for page

Cited passage

Style
Citations are available only to our active members.
Sign up now to cite pages or passages in MLA, APA and Chicago citation styles.

"Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences." (Einhorn, 1992, p. 25).

"Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences." (Einhorn 25)

"Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences."1

1. Lois J. Einhorn, Abraham Lincoln, the Orator: Penetrating the Lincoln Legend (Westport, CT: Greenwood Press, 1992), 25, http://www.questia.com/read/27419298.

Cited passage

Welcome to the new Questia Reader

The Questia Reader has been updated to provide you with an even better online reading experience.  It is now 100% Responsive, which means you can read our books and articles on any sized device you wish.  All of your favorite tools like notes, highlights, and citations are still here, but the way you select text has been updated to be easier to use, especially on touchscreen devices.  Here's how:

1. Click or tap the first word you want to select.
2. Click or tap the last word you want to select.

OK, got it!

Thanks for trying Questia!

Please continue trying out our research tools, but please note, full functionality is available only to our active members.

Your work will be lost once you leave this Web page.

For full access in an ad-free environment, sign up now for a FREE, 1-day trial.

Already a member? Log in now.