The "Environment" for Autism Research: Signs of Improvement?

By Lawler, Cindy P. | Environmental Health Perspectives, October 2008 | Go to article overview

The "Environment" for Autism Research: Signs of Improvement?

Lawler, Cindy P., Environmental Health Perspectives

Once thought to be rare, autism spectrum disorders (ASD) have gained increasing public attention as prevalence studies have revealed sharp increases over the past two decades. ASD now represents the second most common category of neurodevelopmental disorders. The prevalence data have been instrumental in mobilizing parents to act on behalf of their affected family members for better services and treatments and for greater research investments aimed at understanding what causes these disorders and how they can be prevented.

Increased funding for ASD research has led to visible progress in many areas, although the causes for the sharp increase in prevalence remain unresolved. Changes in awareness, diagnostic practices, and availability of services can account for some of the increase, yet a separate role for increased exposure to one or more environmental agents also has been suggested.

The increases in prevalence data also helped fuel speculation regarding a link between the mercury-based vaccine preservative thimerosal and ASD. Many methodologically sound epidemiologic studies have failed to support a causal relationship. Concerns persist for some parents, however, and current time trends remain under scrutiny. The possibility of a small subgroup of children with a unique vulnerability to vaccines or vaccine components has been raised and is more difficult to address.

In light of the persistent public attention to ASD prevalence and to vaccines as potential risk factors, it is surprising that an appreciation for the larger fundamental question of how nongenetic/environmental factors may contribute to ASD has grown slowly. This is unfortunate, because a diverse spectrum of environmental factors merit consideration--from pesticides and other agrichemicals to pharmaceuticals, nutrition, and lifestyle. The full explanation for the relative lack of attention to environmental hypotheses is complex. Contributing influences are likely to include the contemporary scientific focus on genetic etiologies of ASD, the possible reluctance of Investigators to enter an arena that included the controversial issue of vaccines as risk factors, the lack of strong etiologic clues to pursue, and the need to build new investigative teams and infrastructure that can support sustained research in this nascent area. A recent Institute of Medicine meeting on autism and the environment (Autism and the Environment: Challenges and Opportunities for Research, Washington, DC, 16-17 April 2007) highlighted the continuing challenges and opportunities for research in this area (Altevogt et al. 2008).

Despite the relatively tepid scientific interest in the environment and autism over the past 8 years, there have been signs of progress. A U.S. surveillance network established by the Centers for Disease Control and Prevention (CDC) is now in place to aid detection and interpretation of future trends (Rice et al. 2007). In 2001, a Center for Children's Environmental Health and Disease Prevention whose focus is on ASD was established at the University of California-Davis with support from the National Institute of Environmental Health Sciences and U.S. Environmental Protection Agency. The Center brought new investigators into the field of autism and environmental health sciences and incorporated methods of community engagement that built trust between researchers and parent advocates; this, in turn, enriched the science being conducted and enhanced the ability to disseminate scientific results produced by the studies. Interdisciplinary collaborations among investigators at the Center make it possible to tackle questions using multiple approaches, from human studies to animal and cellular models.

One key component of the University of California-Davis Center has been the CHARGE (Childhood Autism Risks from Genetics and the Environment) study, the first large scale population-based case-control epidemiology study of environmental and genetic risk factors for autism. …

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