New Research Seeks to Head off Diabetes

Daily Herald (Arlington Heights, IL), July 6, 2009 | Go to article overview

New Research Seeks to Head off Diabetes


Byline: Lauran Neergaard Associated Press

PITTSBURGH u The doctor had barely pulled away the needle when a blister appeared on Tracey Berg-FultonAEs abdomen: An experimental shot was revving up the 24-year-oldAEs immune system u part of a bold quest to create a vaccinelike therapy for diabetes.

"If weAEre right, that is whatAEs going to stop type 1 diabetes," said Dr. David Finegold as he watched the blisters appear u one to match each of four shots u with satisfaction.

ItAEs a big "if." The research is in its infancy, an experiment to be sure the vaccine approach is safe before researchers at ChildrenAEs Hospital of Pittsburgh test their real target u kids newly diagnosed with this deadliest form of diabetes.

ItAEs also part of a big shift: Scientists increasingly hope to control type 1 diabetes by curbing the rogue immune cells that cause it, before patients become completely dependent on daily insulin injections to survive.

"Treating at onset in children is the best chance we have," said Pittsburgh immunologist Dr. Massimo Trucco, whose novel vaccine u made from patientsAE own blood u is among a handful of possible immune therapies being tested around the country.

About 3 million Americans have type 1 diabetes, where the body mistakenly attacks and destroys cells in the pancreas that produce insulin, the hormone crucial to converting blood sugar to energy. ItAEs different from the more common type 2 diabetes that is usually linked to obesity, where the body produces insulin but gradually loses the ability to use it properly.

Type 2 patients have more treatment options, including diet and exercise.

To stay alive, type 1 patients must rigorously inject insulin, or wear a pump that infuses it.

"It bothers me all the people who say, aeCanAEt you just exercise and get rid of it?AE" said Berg-Fulton of Millvale, Pa., who was diagnosed just before her 10th birthday. "Type 2 gets all the attention. This is type 1 u we die from this."

Hence the new push for immune therapy. Preserve enough precious insulin-producing cells before irreversible damage is done and maybe patients would need far less insulin, perhaps only occasional injections like when they splurge on ice cream.

But how? A "therapeutic vaccine" must shut down T cells that are the immune systemAEs attack dogs, racing out to tackle infections or other invaders u but only the faulty ones that erroneously attack a type 1 diabeticAEs own pancreas. …

The rest of this article is only available to active members of Questia

Sign up now for a free, 1-day trial and receive full access to:

  • Questia's entire collection
  • Automatic bibliography creation
  • More helpful research tools like notes, citations, and highlights
  • Ad-free environment

Already a member? Log in now.

Notes for this article

Add a new note
If you are trying to select text to create highlights or citations, remember that you must now click or tap on the first word, and then click or tap on the last word.
One moment ...
Default project is now your active project.
Project items

Items saved from this article

This article has been saved
Highlights (0)
Some of your highlights are legacy items.

Highlights saved before July 30, 2012 will not be displayed on their respective source pages.

You can easily re-create the highlights by opening the book page or article, selecting the text, and clicking “Highlight.”

Citations (0)
Some of your citations are legacy items.

Any citation created before July 30, 2012 will labeled as a “Cited page.” New citations will be saved as cited passages, pages or articles.

We also added the ability to view new citations from your projects or the book or article where you created them.

Notes (0)
Bookmarks (0)

You have no saved items from this article

Project items include:
  • Saved book/article
  • Highlights
  • Quotes/citations
  • Notes
  • Bookmarks
Notes
Cite this article

Cited article

Style
Citations are available only to our active members.
Sign up now to cite pages or passages in MLA, APA and Chicago citation styles.

(Einhorn, 1992, p. 25)

(Einhorn 25)

1

1. Lois J. Einhorn, Abraham Lincoln, the Orator: Penetrating the Lincoln Legend (Westport, CT: Greenwood Press, 1992), 25, http://www.questia.com/read/27419298.

Cited article

New Research Seeks to Head off Diabetes
Settings

Settings

Typeface
Text size Smaller Larger Reset View mode
Search within

Search within this article

Look up

Look up a word

  • Dictionary
  • Thesaurus
Please submit a word or phrase above.
Print this page

Print this page

Why can't I print more than one page at a time?

Full screen

matching results for page

Cited passage

Style
Citations are available only to our active members.
Sign up now to cite pages or passages in MLA, APA and Chicago citation styles.

"Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences." (Einhorn, 1992, p. 25).

"Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences." (Einhorn 25)

"Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences."1

1. Lois J. Einhorn, Abraham Lincoln, the Orator: Penetrating the Lincoln Legend (Westport, CT: Greenwood Press, 1992), 25, http://www.questia.com/read/27419298.

Cited passage

Welcome to the new Questia Reader

The Questia Reader has been updated to provide you with an even better online reading experience.  It is now 100% Responsive, which means you can read our books and articles on any sized device you wish.  All of your favorite tools like notes, highlights, and citations are still here, but the way you select text has been updated to be easier to use, especially on touchscreen devices.  Here's how:

1. Click or tap the first word you want to select.
2. Click or tap the last word you want to select.

OK, got it!

Thanks for trying Questia!

Please continue trying out our research tools, but please note, full functionality is available only to our active members.

Your work will be lost once you leave this Web page.

For full access in an ad-free environment, sign up now for a FREE, 1-day trial.

Already a member? Log in now.