Approaches to Human Health Risk Assessment Based on the Signal-to-Noise Crossover Dose

Chiu, Weihsueh A., Guyton, Kathryn Z., Hogan, Karen, Jiont, Jennifer, Environmental Health Perspectives

We acknowledge the effort of Sand et al. (2011) in striving to develop a transparent, objective procedure for point of departure (POD) estimation, as encouraged by scientific review groups (National Research Council 2009). Although additional characterization of the statistical properties of the signal-to-noise crossover dose (SNCD) may be warranted, the goal of Sand et al. (2011) appears consistent with the intent of the POD to characterize "the beginning of extrapolation to lower doses" [U.S. Environmental Protection Agency (EPA) 2005]. In this letter we respond to the authors' illustration of their approach using cancer bioassay data to develop reference doses (RfDs) that target a 1/1,000 risk through linear extrapolation from the POD by highlighting opportunities to augment their statistically based approach with biological considerations.

For most carcinogens, …

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Publication information: Article title: Approaches to Human Health Risk Assessment Based on the Signal-to-Noise Crossover Dose. Contributors: Chiu, Weihsueh A. - Author, Guyton, Kathryn Z. - Author, Hogan, Karen - Author, Jiont, Jennifer - Author. Journal title: Environmental Health Perspectives. Volume: 120. Issue: 7 Publication date: July 2012. Page number: A264. © 2006 National Institute of Environmental Health Sciences. COPYRIGHT 2012 Gale Group.

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