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Gene Mutations Affect Cognition, Emotions. (Imaging Studies)

By: Evans, Jeff | Clinical Psychiatry News, February 2003 | Article details

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Gene Mutations Affect Cognition, Emotions. (Imaging Studies)


Evans, Jeff, Clinical Psychiatry News


BETHESDA, MD. -- Specific mutations to single genes may help predispose some patients to abnormal behaviors, Dr. Daniel R. Weinberger said at a psychopharmacology update sponsored by the National Institute of Mental Health.

In imaging studies, seemingly insignificant polymorphisms in three well-studied genes have been observed to have a relatively large impact on information processing and emotional responses.

Several studies have focused on the effects of a single-base pair substitution in the gene that codes for catechol-O-methyl-transferase (COMT), which breaks down dopamine, said Dr. Weinberger, chief of the clinical brain disorders branch of the National Institute of Mental Health.

The mutation makes the COMT enzyme about …

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