Drosophila Mus301/spindle-C Encodes a Helicase with an Essential Role in Double-Strand DNA Break Repair and Meiotic Progression

McCaffrey, Ruth, St Johnston, Daniel, González-Reyes, Acaimo, Genetics

ABSTRACT

mus301 was identified independently in two genetic screens, one for mutants hypersensitive to chemical mutagens and another for maternal mutants with eggshell defects. mus301 is required for the proper specification of the oocyte and for progression through meiosis in the Drosophila ovary. We have cloned mus301 and show that it is a member of the Mus308 subfamily of ATP-dependent helicases and the closest homolog of human and mouse HEL308. Functional analyses demonstrate that Mus301 is involved in chromosome segregation in meiosis and in the repair of double-strand-DNA breaks in both meiotic and mitotic cells. Most of the oogenesis defects of mus301 mutants are suppressed …

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Publication information: Article title: Drosophila Mus301/spindle-C Encodes a Helicase with an Essential Role in Double-Strand DNA Break Repair and Meiotic Progression. Contributors: McCaffrey, Ruth - Author, St Johnston, Daniel - Author, González-Reyes, Acaimo - Author. Journal title: Genetics. Volume: 174. Issue: 3 Publication date: November 2006. Page number: 1273+. © Genetics Society of America Feb 2009. Provided by ProQuest LLC. All Rights Reserved.

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