A summary of current articles from that pile on your desk
Aspirin Resistance Affects Cardiovascular Disease
J Am Coll Cardiol. 2008;51:1829-1843 [May 13, 2008]
Although aspirin is very effective for secondary prevention of vascular disease, British researchers note that up to 60 percent of patients do not respond adequately to aspirin therapy. This resistance can have important implications for the treatment of cardiovascular diseases, such as diabetes, hypertension, and heart failure.
Secondhand Smoke's Cellular Effects Measured
J Am Coll Cardiol. 2008;51:1760-1771 [May 6, 2008]
Researchers at University of California, San Francisco, analyzed data from 10 healthy nonsmokers who were exposed to 30 minutes of secondhand smoke on two days, at levels often found in the smoking areas of bars and restaurants. It led to acute vascular injury and an increase of circulating dysfunctional endothelial progenitor cells.
Carotid Bruits Are Coronary Risk Equivalent
Lancet. 2008;371:1587-1594 [May 10, 2008]
Carotid bruits are useful in predicting which patients are at elevated risk of myocardial infarction or cardiovascular death, say investigators at the Walter Reed Army Medical Center in Washington, DC. In four studies, patients with carotid bruits had more than twice the risk of myocardial infarction and cardiovascular death than those without bruits.
Metformin, Insulin Show Similar Neonatal Effects
New Engl J Med 2008;358:2003-2015 [May 8, 2008]
The use of metformin or insulin in women with gestational diabetes is associated with similar rates of perinatal complications, such as infant hypoglycemia, respiratory distress, and prematurity, according to researchers in New Zealand.
Cholesterol Levels Vary in Short Term
Ann Internal Med 2008; 148:656-661 [May 6, 2008]
Individual cholesterol level measurements vary by at least 7 percent in the short term, and apparent increases in annual cholesterol levels may be false positives for the first three years of treatment for patients taking cholesterol-lowering drugs, British investigators report.
Most Osteoporosis Drugs Prevent Fractures Equally
Ann Internal Med. …