syndrome ( Andrews, 1996). Therefore, it is logical to assume that at least a sizable proportion of the variance in AS is likely to be genetically determined.
Recently, speculation on the origins of anxiety disorders has begun to incorporate genetic vulnerability, family factors, socialization experiences, and specific life events ( Hudson & Rapee, in press; Rapee, 1997). AS, a subcomponent of trait anxiety ( Lilienfeld, 1996), is likely to be mediated by the same factors. It may be that the heritable component of AS serves as a necessary template for the development of panic disorder and that the experientially derived component of AS serves as the trigger that determines which predisposed individuals will express the disorder. Thus, a home for both biology and psychology could be found within the theoretical framework of panic disorder etiopathology. At present, no data directly address the possibility that AS might be inherited. A clearer understanding of the relationship between AS and the neurobiology of panic disorder awaits the conduct of these studies.
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