Behavioural Pharmacology of 5-HT

Table of contents

• Title Page i
• Table of Contents iii
• Preface vii
• I 1
• Introduction 1
• Behavioral Pharmacology Of-Ht: An Introduction 4
• 2 Is Rotational Behaviour in the Rat A 5-Ht1a or 5-Ht1b Mediated Response? 22
• 3: Serotonin-Mediated Behaviour Following Central or Peripheral Administration of the Selective Nk-3 Tachykinin Agonist Senktide 27
• Ii 5-Ht. and Sexual Behaviour. 33
• New Aspects on the Serotonergic Modulation of Male Rat Sexual Behaviour 36
• Introduction 35
• References 47
• 5 Differential Roles of 5-Ht Receptor Subtypes in Female Sexual Behaviour 57
• Conclusions 63
• References 65
• Hypothalamic Sites of Action of the Dual Effect of 5-Ht on Female Sexual Behaviour in the Rat 73
• 5-Ht1a and 5-Ht1b Agonists Produce Opposite Effects on the Ejaculatory Response Induced by Amphetamine in Rats 79
• Functional Interplay of Serotonin (5-Ht)-Receptor Subtypes 84
• Iii 5-Ht & Aggression 87
• 9 Modulatory Action of Serotonin in Aggressive Behaviour 92
• Introduction 89
• References 108
• 10 Brain 5-Ht System and Inhibition of Aggressive Behaviour 118
• Conclusions 130
• References 132
• 11: Differential Effects of Benzodiazepines and 5-1-Ht1a Agonists on Defensive Patterns in Wild Rattus 145
• Competition for Sucrose-Pellets in Triads of Male, Wistar Rats: the Effects of Eight 5-Ht-Agonists 149
• Iv Depression and Psychosis 153
• 13: Towards A Theory of Serotonergic Dysfunction in Depression 157
• 14 5-Ht Receptor Subtypes in Depression 181
• Modulation of the 5-Ht System and Antipsychotic Activity 207
• References 219
• 16: Mechanism of Action of 8-Oh-Dpat on A Rat Model for Human Depression 225
• 17: Reversal of Helpless Behaviour in Rats by Serotonin Uptake Inhibitors 231
• Ritanserin (r 55 667), an Original Thymosthenic 235
• References 238
• 19: The Abilities of 5-Ht3 Antagonists to Inhibit the Hyperreactivity Caused by Dopamine Infusion into the Nucleus Accumebens of the Rat 239
• 5-Ht2 Antagonists Increase Tactile Startle Habituation in an Animal Model of A Habituation Deficit in Schizophrenia 243
• Feeding Behaviour 247
• Pharmacological Evidence for the Involvement of Serotonergic Mechanisms in Human Feeding 250
• Introduction 249
• Conclusions 255
• References 256
• Serotonin and Feeding 260
• Conclusions 271
• References 272
• 23: Opposite Effects of 5-Ht1a and 5-Ht1b/1c Agonists on Food Intake 283
• 24: Effects of Selective Serotonergic Agonists on Palatability-Induced Ingestion 287
• 25: 8-Oh-Dpat Reliably Increases Ingestion of Solid but Not Liquid Diets 291
• 26: Pharmacological Manipulation of 5-Ht: Effect on Intake of Diets Supplemented with Either Sweet or Bland Carbohydrates 295
• Vi 5-Ht, Pain and Anxiety 299
• Vi 5-Ht, Pain and Anxiety 301
• References 313
• The Relationship Between Various Animal Models of Anxiety, Fear-Related Psychiatric Symptoms and Response to Serotonergic Drugs 321
• References 331
• 5-Ht1a Receptors: A Bridge Between Anxiety and Depression? 337
• 30: A Review of the Evidence Supporting the Anxiolytic Potential of 5-Ht3 Receptor Antagonists 353
• 31: Ultrasonic Vocalizations by Rat Pups as an Animal Model for Anxiolytic Activity: Effects of Serotonergic Drugs 361
• 32: Effects of the 5-Ht1a Agonist Ipsapirone on the Behavioural, Endocrine and Neurochemical Responses to Conditioned Fear 367
• 33: Buspirone, Epsapirone and 5-Ht1-Receptor Agonists Show an Anxiogenic-Like Profile in the Elevated Plus-Maze 371
• 34 Antianxiety Effect of Various Putative 5-Ht1 Receptor Agonists on the Conditioned Defensive Burying Paradigm 378
• 35: The Anxiolytic Activities of the 5-Ht3 Receptor Antagonists Gr39032f, Ics 205-930 and Brl 43694 383
• 36 Behavioural Effects of 5-Ht3 Antagonists in Animal Models for Aggression, Anxiety and Psychosis 390
• Vii 5-Ht: Drug Discrimination and Aversion 397
• References 403
• Receptor Mechanisms of the Discriminative Stimulus Properties of Putative Serotonin Agonists 407
• Stimulus Properties of Arylpiperazine Second Generation Anxiolytics 445
• Behavioural, Neurochewcal and Discriminative Stimulus Effects of Spiroxatrine, A Putative 5-Ht1a` Receptor Antagonist 450
• Rapid Training of the Stimulus Properties of Selective 5-Hydroxytryptamine1a Agonists 453
• Behavioural Pharmacology of 5-Ht: Possible Progress in the Laterality of Concepts 459
• References 468
• Author Index 475
• Subject Index 503

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