June 17. Pánfilo de Narváez sails from Spain to explore and settle Florida.
December 13. Charles V decrees that an audiencia of five shall take over the government of New Spain.
Nuño de Guzmán is made president of Pánuco, a province which had been detached from Fernando Cortés' domain of New Spain.
Spring. Cortés leaves Mexico for Spain to answer charges before Charles V.
April 14. Narváez party lands at Tampa Bay.
November. The boats of the Narváez expedition are wrecked on Misfortune Island near Galveston Bay and the expedition ends in failure.
January 1. The audiencia headed by Guzmán takes over administration of New Spain from Alonso de Estrada.
November 5. Royal license is issued to Cortés in Spain to explore and conquer islands of the Pacific and unknown coasts of the mainland.
December 20. Guzmán leaves Mexico City with army of five hundred Spaniards and eight thousand Indians to conquer New Galicia.
Death of Alonso de Estrada, royal treasurer of New Spain and father of Coronado's future wife.