Neural Darwinism: The Theory of Neuronal Group Selection

By Gerald M. Edelman | Go to book overview
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4
Developmental Bases
of Diversity:
The Primary Repertoire

Molecular approaches to the origin of neuronal diversity 74 · The fundamental problem of developmental biology 75 · Primary processes of development 75 · Cell surface modulation 78 · Sequential expression of CAMs in development 83 · Perturbation of pattern by blockade of CAM function 89 · Causal roles of CAMs in induction: the feather 92 · The regulator hypothesis 93 · CAM rules 93 · Dynamic patterning of neural structures 101 · Chemoaffinity markers versus modulation 102


INTRODUCTION

A central feature of the theory of neuronal group selection is that the mechanisms leading to the formation of both the primary and the secondary repertoires are epigenetic: while bounded by genetic constraints, events occurring at both developmental and experiential stages of selection lead to increases with time in both heterogeneity and spatial diversity of cells and cellular structures. Such events depend upon the prior occurrence of other events in time courses that are long compared with those of intracellular events, and the cells involved exhibit interactive and cooperative spatial orderings that could not have been stored directly in the genetic code.

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