CHAPTER 3 SCIENTIFIC BACKGROUND OF THE CRON DIET: THE ANIMAL EVIDENCE INTRODUCTION TO EVIDENCE BEFORE WE ESCALATE TO HUMANS, IT'S IMPORTANT that you be convinced beyond any reasonable doubt that in experimental animals the CRON diet works dramatically at slowing the aging process, preventing disease, and enhancing health. There is now abundant hard evidence--not testimonial evidence, not clinical anecdote, not "make the case" evidence based on plausibil- ity arguments, and not even correlational evidence, although all these exist in plenitude--but hard, well-controlled and steadfastly con- firmed experimental evidence that a CRON diet will greatly extend average and maximum life spans, postpone the onset and decrease the frequencies of most or all of the "diseases of aging," maintain bio- markers at levels younger than the chronological age, maintain sexual potency, general vitality, and ability to engage in sports into advanced age, and delay deterioration of the brain. In 1935 Dr. Clive McCay at Cornell University first demonstrated that if rats from the time of weaning were fed a calorically restricted but healthful diet supplemented with vitamins and minerals, they would live remarkably longer than normally fed rats. 1 By 1,000 days of age, all the normally fed rats had died, but most of the calorie- restricted ones were still alive and active. Their growth rate and body size had been retarded by the severe restrictive regimen, but in other ways they seemed super healthy. If they were allowed a full diet at -45- |