An Illustrated Pocketbook of Parkinson's Disease and Related Disorders

An Illustrated Pocketbook of Parkinson's Disease and Related Disorders

An Illustrated Pocketbook of Parkinson's Disease and Related Disorders

An Illustrated Pocketbook of Parkinson's Disease and Related Disorders

Synopsis

An authoritative introduction to Parkinson's disease and its related disorders and syndromes, this book provides a concise overview of the disease and its diagnosis and management. The author presents samples of clinical, investigative (CT, MRI, and PET) and pathological images with succinct descriptive text of the disorders featured. He describes the conditions related to Parkinson's disease, and the pictures provide pathological macroscopic and microscopic sections, various imaging studies, and details of movement disorders in general. The book will serve as a useful teaching tool that demonstrates the imaging and pathology of the disease.

Excerpt

The neurons of the corpus striatum receive an excitatory input from the cerebral cortex and the thalamus. The major outputs project to the globus pallidus and the substantia nigra pars reticula (SNr), and use gamma-aminobutyric acid (GABA) as a transmitter. Major efferent pathways from the globus pallidus interna and the SNr project to the thalamus. Feedback to the striatum is through the dopaminergic striatonigral pathway originating in the substantia nigra pars compacta (SNc; Figure 1).

These separate pathways utilize different neuropeptides and dopamine receptors. The direct pathway from the striatum to the globus pallidus interna (GPi) and SNr expresses substance P and dynorphin, and uses D1 dopamine receptors. The neurons projecting from the striatum to the external segment of the globus pallidus (GPe) express enkephalin and use D2 receptors. (Some neurons express both receptors.)

Figure 1 Major pathways of the basal ganglia. Modified from Riley DE, Lang AE. In Bradley WG, et al., Neurology in Clinical Practice. London: Butterworth Heinemann, 1996

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