Obesity and Cardiovascular Disease

Obesity and Cardiovascular Disease

Obesity and Cardiovascular Disease

Obesity and Cardiovascular Disease


The number of individuals who are obese or overweight has dramatically increased over recent years and is now becoming epidemic.These individuals are more likely to suffer cardiovascular diseases and therefore physicians, specialists and trainees increasingly need to deal with these issues on the ward and in clinic. As a result, the need for appropriate knowledge of up-to-date clinical management of obesity and its associated cardiovascular problems is essential for any practising physician. Obesity and Cardiovascular Disease is a readily assimilated pocket guide to obesity and cardiovascular disease. It is intended to be used 'on-the-go' and is compact enough to be on hand whilst in consultation with patients. It provides a clear and succinct overview of contemporary clinical management of cardiovascular risk stratification, and fully covers the diagnosis and treatment of cardiovascular in obese patients and individuals with increased visceral adiposity, translating up-to-date clinical research findings into clinical practice. Particular emphasis is placed on recent updates in practical care in obesity and cardiovascular disease, such as new diagnostic techniques and novel pharmacological and surgical approaches, as well as cardiac visceral fat, ethnic differences in adiposity-related cardiovascular risk, and metabolically healthy, but obese subjects. Topics are presented in an easily accessible format with numerous illustrations, photographs, tables, diagnosticand therapeutic algorithms while highlight boxes summarise the main concepts discussed in each chapter.


Obesity has now overtaken smoking as the principal risk factor for cardiovascular disease in most Western societies. The root causes of the obesity epidemic are complex; despite major efforts, the global increase in obesity rates continues to rise and childhood obesity is rampant.

Not only does obesity contribute to cardiovascular disease as a risk factor, but it is now also evident that adipose tissue itself produces a vast array of molecules (adipokines) that directly influence cardiovascular and metabolic function. Thus, for example, the adipose-tissuederived factor leptin not only plays an important role in the regulation of energy homeostasis, but also increases sympathetic nerve activity, thereby increasing cardiac output and promoting volume retention. Other adipose-tissue-derived factors such as visfatin, resistin, and adiponectin are likewise recognized to play important roles in the obesity-related pathologies of the cardiovascular system.

Despite the recognition that obesity is an important mediator of cardiovascular risk, our ability to clinically address and manage obesity remains limited. Short of bariatric surgery, we still lack hard outcome data on the effects of weight loss on cardiovascular mortality. Nevertheless, current behavioral and medical approaches to obesity management do have significant beneficial effects on other cardiovascular risk factors and it appears prudent that weight loss is recommended as a first-line treatment to anyone in whom excess weight appears to be contributing to hypertension, dysplipidemia, or type 2 diabetes mellitus.

For clinicians dealing with obesity-related health problems, this compendium on obesity and cardiovascular disease could not come at a better time. Not only has Prof. Iacobellis himself made significant research contributions to the field (for example, on the role of epicardial fat), but he has succeeded in summarizing for the busy clinician the major discoveries, treatments, and controversies in obesity-related . . .

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