An Outline of Chemical Genetics

An Outline of Chemical Genetics

An Outline of Chemical Genetics

An Outline of Chemical Genetics

Excerpt

This book discusses the following ideas which form a conceptual scheme for present day chemical genetics:

1. The genetic detemininants of organisms are particulate in nature and occur linked together in linear fashion. Occasionally changes in the linkage relationships may occur during, or closely following, the time of the duplication of the genetic material. Such recombination of genetic characteristics constitutes the basic fact of genetics as a separate science.

2. The genetic information is carried from generation to generation by a chemical substance -- deoxyribonucleic acid (DNA). This substance is a polymer built of four nucleotides arranged to form a double helix. The helix is so arranged that each strand is an exact complement of the other. The genetic information is coded in the DNA so that the sequence in which the four nucleotides occur constitutes an "alphabet" which spells out the genetic information.

3. The genetic material acts by controlling the formation of proteins. Genes not only control the quantitative presence or absence of particular proteins but they also determine the qualitative properties of the proteins which are formed. This control of protein characteristics occurs by genetic control of the sequence of amino acids in the protein polypeptide chains. The code of nucleotides determines the sequence of the amino acids, and changes in the sequence of nucleotides are reflected by changes in the sequence of amino acids in the corresponding protein.

4. Occasional errors in the duplication of the nucleotide code . . .

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