Academic journal article Environmental Health Perspectives

Gene-Environment Interaction. (Headliners: NIEHS-Supported Research)

Academic journal article Environmental Health Perspectives

Gene-Environment Interaction. (Headliners: NIEHS-Supported Research)

Article excerpt

Effect of Polymorphisms on Biomarkers in Coal Miners

Nadif R, Jedlicka A, Mintz M, Bertrand J-P, Kleeberger S, Kauffmann F. 2003. Effect of TNF and LTA polymorphisms on biological markers of response to oxidative stimuli in coal miners: a model of gene-environment interaction. J Med Genet 40:96-1.03.

Genetic polymorphisms have been implicated in the difference in response to environmental agents, but interactions between genes and environmental oxidants involved in the development of human lung diseases have been largely unexplored. Oxidative stress arising from cigarette smoking and long-term exposure to dust and particles causes chronic airway inflammation, which is essential to the development of many lung diseases such as asthma, chronic obstructive pulmonary disease, and coal workers' pneumoconiosis. In a study of 253 coal miners in France, NIEHS grantee Steven Kleeberger and colleagues investigated whether polymorphisms in two genes coding for the proinflammatory cytokines tumor necrosis factor [alpha] (TNF) and lymphotoxin-[alpha] (LTA) modify lung response to oxidants.

Specifically, the researchers measured intermediate biomarkers of response to oxidant exposure, including glutathione peroxidase (GSH-Px) and catalase activity in red blood cells among miners genotyped for the two polymorphisms. …

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