Academic journal article Bulletin of the World Health Organization

Nomenclature for Human Complement Component C2

Academic journal article Bulletin of the World Health Organization

Nomenclature for Human Complement Component C2

Article excerpt

This note describes the designations for variants of the human complement component C2, which were approved by the Nomenclature Committee of the International Union of Immunological Societies (IUIS).

C2 variants

The reference typing recommended by the Sixth Complement Genetics Workshop permits nine electrophoretic variants of C2 to be distinguished (Fig. 1). In addition to the common form C2 C, four acidic variants and four basic variants are observed (Table 1).

Differences in pI between variants are difficult to establish. We therefore propose to designate the variants according to their relative IEF migration, taking the distance between the two major bands of the common C2 C as a reference unit. This distance has been estimated to be approximately 0.1 pH interval [3]. As initially proposed, the common C2 allele is called C2*C; the acidic and basic alleles are designated C2*A and C2*B, respectively [1, 2]. The numeric symbols, corresponding to the relative migration value, clearly permit the rare acidic and rare basic variants to be differentiated. However, the most common basic variant (approximate gene frequency, 0.02 to 0.04), designated in this nomenclature as B03, may still in common usage be named C2 B. The nomenclature of all the variants tested for the Workshop is given in Fig. 1 and conforms to the guidelines of the international system for human gene nomenclature [6]. …

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