Academic journal article Environmental Health Perspectives

Parental Chemical Exposures and Ras Mutations in Children

Academic journal article Environmental Health Perspectives

Parental Chemical Exposures and Ras Mutations in Children

Article excerpt

Shu xo, Perentesis JP, Wen w, Buckley JD, Boyle E, Ross JA, Robison LL; Children's Oncology Group. 2004. Parental exposure to medications and hydrocarbons and ras mutations in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group. Cancer Epidemiol Biomarkers Prey 13(7):1230-1235.

A variety of carcinogens have been shown to induce ras mutations in animal and human tumor models, and ras proto-oncogene mutations have been implicated in the development of many malignancies including pancreatic and breast cancers. However, few data exist associating parental exposures and ras mutations in their children. Now a team including NIEHS grantee Leslie L. Robison of the University of Minnesota report that parents' chemical exposures may be associated with distinct ras mutations in their children with acute lymphoblastic leukemia (ALL).

This study used data from a large case-control study of childhood ALL conducted by the Children's Oncology Group in Southern California. DNA samples from the study children were examined for ras mutations. A total of 127 out of 837 ALL cases exhibited ras mutations in the K- or N-ras genes. Earlier studies have reported a 5-20% frequency of ras mutations among patients with ALL.

A number of parental chemical exposures were associated with significantly increased risks for ras mutation in the children. …

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