Academic journal article Bulletin of the World Health Organization

Recommendations for the Composition of Influenza Virus Vaccines for the 1993-94 Season

Academic journal article Bulletin of the World Health Organization

Recommendations for the Composition of Influenza Virus Vaccines for the 1993-94 Season

Article excerpt

During the 1992-93 season, influenza A (H3N2), A (H1N1) and influenza B viruses all continued to circulate.

Influenza B viruses were the most prevalent and were antigenically related to B/Panama/45/90. Vaccines containing B/Yamagata/16/88-like or B/Panama/45/90-like viruses induced antibodies with similar frequencies and titres both to the vaccine viruses and to representative recent isolates.

Vaccines containing influenza A/Singapore/6/86 (H1N1)-IIKE viruses induced satisfactory antibody responses to representative recent isolates.

The predominant influenza A (H3N2) viruses showed antigenic differences from the vaccine strain A/Beijing/353/89 and were antigenically similar to A/Beijing/32/92. Vaccines containing A/Beijing/353/ 89-like viruses induced antibody responses to A/ Beijing/32/92-like viruses at lower frequency and titre than to the vaccine virus.

Consequently, it is recommended that trivalent vaccines be used in the 1993-94 season, and that they contain the following: * an A/Beijing/32/92(H3N2)-like strain; * an A/Singapore/6/86(H1N1)-like strain; and * a B/Panama/45/90-like strain;

As in previous years the specific viruses used in each country should be approved by the national control authorities.

Most of the population is likely to have been infected with influenza A (H3N2), influenza A (H1n1) and influenza B viruses in recent years. …

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