Academic journal article Environmental Health Perspectives

The NIH ENDGAME Consortium

Academic journal article Environmental Health Perspectives

The NIH ENDGAME Consortium

Article excerpt

The NIH has recently established a highly interactive consortium of 11 research groups on Enhancing Development of Genome-wide Association Methods (ENDGAME) to advance the utility of genome-wide association studies. The consortium (funded by the NHLBI, NIEHS, NCI, NHGRI, and NIGMS) brings together expertise in genetics, epidemiology, biostatistics, and bioinformatics to develop and test innovative, informative, and cost-effective study designs and analytical strategies for performing genome-wide association studies on complex diseases. Available resources such as the International Haplotype Mapping (HapMap) data and single nucleotide polymorphism (SNP) discoveries along with improvements in genome technologies have increased the feasibility of genome-wide association studies for complex diseases. However, it has become increasingly apparent that a major barrier to successfully completing these studies is a lack of both appropriate analytical tools and understanding of which study designs and computational methods are most appropriate for particular study scenarios.

The NIEHS is most interested in the development of analytical tools and approaches that would allow identification of environmental components or covariates of complex diseases in genome-wide association studies. Although most common chronic diseases are the result of complex interactions between genes (G) and environmental (E) factors, most analytical approaches adopted for whole genome scans do not incorporate interactive effects with environmental factors. …

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