Academic journal article Environmental Health Perspectives

Man's Worst Friend? TCDD and Male Reproductive Effects

Academic journal article Environmental Health Perspectives

Man's Worst Friend? TCDD and Male Reproductive Effects

Article excerpt

Animal studies indicate that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds are reproductive and developmental toxicants, but effects of human exposures are unclear. Five months after the January 1999 accidental contamination of animal feed with polychlorinated biphenyls and TCDD in Belgium, a research team collected blood and semen samples from 101 men aged 20 to 40 living in Antwerp and Peer [EHP 114:1670-1676; Dhooge et al.]. The resulting analysis is the first to link exposure to TCDD and dioxin-like compounds to male reproductive effects in the general population.

Blood sample hormone analysis yielded measurements for total testosterone, luteinizing hormone, follicle-stimulating hormone, sex hormone-binding globulin, total 17[beta]-estradiol, and inhibin B. Free testosterone was calculated from total testosterone and sex hormone-binding globulin values. Blood samples were also used to assay for compounds with the ability to bind to aryl hydrocarbon receptor, the target of TCDD; these results were expressed as a TCDD equivalent (TEQ). …

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