Academic journal article The Science Teacher

Salmonella to Administer Vaccines

Academic journal article The Science Teacher

Salmonella to Administer Vaccines

Article excerpt

Researchers at the Biodesign Institute at Arizona State University (ASU) have made a major step forward in their work to develop a biologically engineered organism that can effectively deliver an antigen in the body. The researchers report that they have been able to use live Salmonella bacterium as the containment and delivery method for an antigen.

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The work is a major step forward in development of a new means of biological containment that would be a key component to a new way to deliver vaccines in animals and humans. If fully developed, the new method could be used to administer vaccines to many of those who do not benefit from traditional vaccines because of cost, drug resistance, or the limited effects on children.

The findings are published in the online version of the Proceedings of the National Academy of Sciences. The researchers describe a new, novel, and effective means of biological containment for antigen delivery. The method not only effectively delivers the antigen in the body, but does so in a way that does not infect the body with Salmonella and does not leave any vaccine cells in the environment.

"We wanted to do this in a way so that no disease symptoms due to Salmonella would arise, a protective immune response would be induced to the pathogen whose protective antigen was delivered by the vaccine construction (in this case against Streptococcus pneumoniae due to an immune response to PspA), and there would be no ability for live bacterial vaccine cells to either persist in vivo or to survive if shed into the environment," says Roy Curtiss, director of the Center for Infectious Diseases and Vaccinology at the Biodesign Institute and a professor in ASU's School of Life Sciences. …

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