Academic journal article The Science Teacher

Good versus Bad Cells

Academic journal article The Science Teacher

Good versus Bad Cells

Article excerpt

Cancer cells and nervous system neurons may not look or act alike, but both use strikingly similar ways to survive, according to new research from the University of North Carolina (UNC)--Chapel Hill School of Medicine. The study published in Nature Cell Biology is the first to describe how neurons (nerve cells) and cancer cells (see image above) achieve the common goal of inhibiting the series of biochemical events called "apoptosis" that eventually causes cells to break down and die.

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That is good in the case of neurons, but bad when it comes to cancer. "In neurons, inhibiting cell death is physiologically important to ensuring their long term survival," says the study's lead author, neurobiologist Mohanish Deshmukh, associate professor of cell and developmental biology and member of the Lineberger Comprehensive Cancer Center. "In cancer cells, blocking cell death allows them to evade the host defense systems and proliferate uncontrollably."

Both neurons and cancer cells do have something in common: relying extensively on the metabolism of glucose, a simple sugar. But until now, the advantages of this common characteristic have remained unclear. "One reason why these results are so interesting is that neurons and cancer cells are as different from each other as you can imagine," Deshmukh says. "For example, cancer cells divide continuously, whereas neurons do not divide at all."

In their research, Deshmukh and UNC graduate student Allyson Vaughn (currently a postdoctoral scientist at the Massachusetts Institute of Technology) found that to prevent death, neurons and cancer cells use a specific metabolic pathway, or series of chemical reactions. …

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