Academic journal article Environmental Health Perspectives

Bisphenol A, Chapter 2: New Data Shed Light on Exposure, Potential Bioaccumulation

Academic journal article Environmental Health Perspectives

Bisphenol A, Chapter 2: New Data Shed Light on Exposure, Potential Bioaccumulation

Article excerpt

Bisphenol A (BPA), an industrial chemical used in a variety of consumer products, is ubiquitous in the modern environment, with residues found in the urine of an estimated 93% of Americans over 6 years of age, according to data from the 2003-2004 National Health and Nutrition Examination Survey (NHANES). Recent research indicates that BPA acts as an endocrine disruptor and may increase the risk of heart disease, diabetes, and liver problems in adults. Until now, most exposure was thought to occur through diet, and the chemical was thought to clear the body quickly and completely. But a new study shows that urine BPA levels of subjects who had fasted for several hours were not as low as expected, suggesting either nondietary exposures or accumulation in fatty tissue, or both [EHP 117:784-789; Stahlhut et al.]

Although BPA is fat-soluble and thus can accumulate in fatty tissues, animal and human data suggest it tends to be rapidly metabolized, with elimination thought to be virtually complete within 24 hours of acute exposure. To gain a better understanding of how BPA clears the body, investigators in the current study used data from 1,469 adult participants in the 2003-2004 NHANES. Study participants (excluding children and insulin-dependent diabetics) had been asked to fast for at least 6--9 hours. Using the urine drawn from each study participant, the investigators modeled log BPA concentration against fasting time, adjusting for urine creatinine and other con-founders, to estimate what they called the "population-based half-life" of BPA for a 0- to 24-hour fasting period. …

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