Synthetic Biology, Analytic Ethics: Small Steps, but Where Are We Going

Article excerpt

The news in May that researchers at the J. Craig Venter Institute had created a synthetic life form brought a fresh round of delight, concern, and puzzlement about the march of biotechnology. And all of these reactions were appropriate. It was surprisingly hard to understand just what JCVI had done.

First off, the technical achievement was less than some thought. JCVI had not actually created a synthetic life form; it had borrowed a naturally occurring cell and inserted into it a synthetic version of a naturally occurring genome. The work was also not obviously a big step forward in the creation of useful synthetic microbes, since that work does not depend on the kinds of organisms used in this research and may not require the synthesis of entire genomes anyway. The work was still a terrific feat, but probably not a game-changer. Craig Venter described it best when he told Congress, in a hearing following the announcement, that it was a "proof of concept" that genomes could be assembled in the lab and inserted into cells.

Philosophically, too, the news was less than billed. Some claimed that science had finally shown, once and for all, that life is just a well-organized puddle of chemicals. Living things have no greater being. But if a Greater Being gives microbes their own little greater being, then it would presumably be well within the Being's powers to endow a synthetic organism with whatever vital essence living organisms typically have. In general, just as a person created through cloning would be as likely as anybody else to have a soul, a microbe created through genome synthesis could have whatever life force characterizes other microbes.

It was also more than a little difficult to say what was at stake morally in the announcement. The initial question in many minds was whether synthesizing a life form was a kind of moral Rubicon in the human relationship to nature--a morally troubling new level of human mastery over nature. Remembering that the achievement was just a synthetic genome, not a life form, may allay that worry. Recognizing that the research does not prove living things have no vital essence might also help. It could also help to recognize that synthetic biology--the field to which the JCVI research contributed--is so far only about microbes, and could be only about microbes with contained, industrial applications. …


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