Academic journal article Environmental Health Perspectives

Passive Sampling for Indoor and Outdoor Exposures to Chlorpyrifos, Azinphos-Methyl, and Oxygen Analogs in a Rural Agricultural Community

Academic journal article Environmental Health Perspectives

Passive Sampling for Indoor and Outdoor Exposures to Chlorpyrifos, Azinphos-Methyl, and Oxygen Analogs in a Rural Agricultural Community

Article excerpt

Introduction

Organophosphorus Pesticides and Oxygen Analogs

In the Yakima Valley region of Washington State, there are more than a thousand orchards (e.g., apples, pears, cherries) covering over 100,000 acres. Washington is the lead producer of apples and cherries in the United States, and 10-12 billion apples are picked each year (USDA 2009) (Figure 1 shows a map of the region). The region is also home to many farmworker families and more than half of the population is Hispanic/Latino (U.S. Census Bureau Geography Division 2010). Most of this population is involved in tree fruit production--harvesting, pruning, thinning, and applying agricultural chemicals (Thompson et al. 2008). In 2011, chlorpyrifos (CPF) and azinphos-methyl (AZM) were some of the most commonly applied organophosphorus (OP) pesticides in tree fruit and vegetable production (Baker and Stone 2015). Both pesticides are often applied in aerosolized form to tree fruits using a large sprayer attached to a tractor. In 2012, the U.S. Environmental Protection Agency (EPA) banned the use of AZM in apple production. Prior to the ban, when this study was conducted, AZM and CPF were commonly sprayed with application rates averaging 0.5 kg/acre and 1 kg/acre active ingredient, respectively (USDA 2008).

The use of OP pesticides in Yakima Valley has long been a health concern of local residents to due to potential human exposures resulting from off target volatilization and drift. In 2008, the state of Washington funded a study to examine off-target movement of OP pesticides and potential risk to bystanders (Fenske et al. 2009). In the 2009 study, CPF, AZM, and their oxygen analogs were identified in the outdoor air of the surrounding agricultural communities, indicating direct atmospheric transformation. Other studies have also reported these compounds in air (Armstrong et al. 2013b; CARB 1998; CDPR 2006, 2009).

Toxicology studies have focused on the relative potency of combined OP pesticides and their oxygen analogs in animal models (Costa et al. 2005), and acknowledge transformation to the oxygen analog in vivo as a metabolic product through breakdown mechanisms involving cytochrome p450 enzymes. Chlorpyrifos-oxon (CPF-O) is poses a special risk for genetically susceptible individuals who have lower levels of the paraoxonase (PON-[1.sup.-/-]) enzyme (Shih et al. 1998), and children may be susceptible to the CPF-O due to differences in their metabolic functioning during development (Barr et al. 2004; Costa et al. 2005). Therefore, it is important to consider the presence of oxygen analogs in the air when measuring human exposure.

In several studies over a decade ago, we found that levels of OP pesticide metabolites in the urine of farmworker children were significantly higher than the levels in the urine of non-farmworker children in the same region (Loewenherz et al. 1997; Lu et al. 2000): These relatively high levels were later confirmed by comparison with national biomonitoring data (Fenske et al. 2005). We also found that pesticide levels in household dust (including AZM and CPF) were higher in farmworker homes than in non-farmworker homes in the same region (Lu et al. 2000; Fenske et al. 2002).

CPF and AZM are both semivolatile compounds, and they exist as both vapor and particle-bound forms in air. This phase-partitioning is highly dependent on a combination of the timing of pesticide application and meteorological factors (Howard 1991). Both compounds can persist for days to weeks outdoors, and for several months indoors (Lewis 2005; Wauchope et al. 1992). There is very little scientific data regarding the long-term atmospheric transport of CPF, AZM, CPF-O, and azinphos-methyl-oxon (AZM-O), and even less is known about their ability to infiltrate indoor environments.

Passive Sampling for Pesticides

To date, many studies have focused on short and long term human health outcomes associated with OP pesticides (Roberts et al. …

Search by... Author
Show... All Results Primary Sources Peer-reviewed

Oops!

An unknown error has occurred. Please click the button below to reload the page. If the problem persists, please try again in a little while.