Academic journal article Bulletin of the World Health Organization

Potential New Drug Treatment for Osteoporosis

Academic journal article Bulletin of the World Health Organization

Potential New Drug Treatment for Osteoporosis

Article excerpt

Osteoporosis is a global health problem that will take on increasing significance as people live longer and the world's population continues to increase. Current treatments have been restricted by a lack of drugs capable of restoring bone mass to normal levels. This situation may be about to change with the discovery of beneficial bone-restoration effects of statins.

Greg Mundy and colleagues in the USA have reported that statins, compounds currently in use to lower blood cholesterol levels, induced significant bone growth in mouse bone cell cultures and also in rats and mice in vivo.(a) If similar effects were observed in humans, statins would offer an effective treatment for those suffering from osteoporosis.

Mundy and co-workers screened 30 000 compounds in an attempt to find potential drug candidates with favourable effects on bone mass. Using a luciferase reporter-gene assay, the researchers looked for compounds that would activate the promoter of the bone morphogenetic protein-2 (BMP-2) gene. Lovastatin was observed in the initial screening to increase luciferase activity in the in vitro assay. When injected subcutaneously into tissue overlying the murine calvaria in live rats, a 50% increase in new bone formation was observed after five days of treatment. …

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