Academic journal article Environmental Health Perspectives

Fellowships, Grants, & Awards

Academic journal article Environmental Health Perspectives

Fellowships, Grants, & Awards

Article excerpt

Molecular Epidemiology of Prostate Carcinogenesis

The National Cancer Institute, the National Institute of Diabetes and Digestive and Kidney Diseases, and the NIEHS invite investigator-initiated research grant applications of molecular epidemiologic studies for advancement in understanding prostate cancer development and progression. The purpose of this initiative is to stimulate development and application of biological markers of prostate cancer risk and tumor aggressiveness and for utilization in chemoprevention studies. Of special interest are studies of markers to elucidate multiethnic differences in prostate cancer susceptibility. Transitional molecular epidemiology studies characterizing and validating biomarkers while determining optimal biological specimens and the most suitable procedures for collection, processing, and storage are encouraged.

Examples of topics of interest to the NCI include 1) etiology and tumor progression, including differences in genetic predisposition due to variations in susceptibility and low-penetrance genes, DNA repair activities, cell cycle progression, or chromosome sensitivity to mutagens or in hormonal metabolism; gene-environment interactions for understanding modification of prostate cancer risk and influence on tumor progression; suspected premalignant processes as independent or joint risk factors that contribute to the transition from latent to invasive cancer; and biologic characteristics in precancerous lesions and tumors that can better define the natural history of prostate cancer and predict prognosis; 2) biomarkers, including assessment and validation of genetic and epigenetic markers that predict tumor progression from localized to disseminated prostate cancer; validation of existing biomarkers of risk in human populations with simultaneous consideration of biological variables and lifestyle risk factors; identification, assessment, and validation of novel biomarkers for early detection and diagnosis, including comparison with current indicators such as PSA; development and clinical validation of new biological markers associated with prostate cancer biology with determination of their role in responses to specific forms of systemic therapy; and development and validation of surrogate markers that can serve as intermediate end points for intervention or clinical trials testing preventive modalities; 3) diet and lifestyle factors; pilot intervention studies of dietary nutrients; role of lifestyle factors, occupational and environmental exposures, sexual behavior, and anthropometry; and effect of dietary intake singly and jointly or interacting with endogenous parameters; and 4) primary prevention.

Examples of topics of interest to the NIDDK include identification of risk factors associated with benign prostatic hyperplasia or chronic prostatitis and clarification of their possible relationships to the development of prostate cancer.

Examples of topics of interest to the NIEHS include 1) elucidation of the role of environmental response genes in the development of prostate cancer; 2) enhanced understanding of the impact of occupational and environmental exposures on the risk of prostate cancer; and 3) exploration and elucidation of the role of timing of environmental exposures during critical periods of normal prostate gland development relevant to future risk of carcinogenesis, and mechanisms by which environmental exposures acting as initiating or promoting agents at various time periods affect the risk and latency of prostate cancer.

This program announcement will expire two years from the first receipt date. Because the nature and scope of the research proposed in response to this announcement may vary, it is anticipated that award size will also vary. Applications are to be submitted on the grant application form PHS 398 and will be accepted at the standard application deadlines as indicated in the application kit. Application kits are available by calling 301-435-0714, e-mailing grantsinfo@nih. …

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