Academic journal article The Canadian Journal of Human Sexuality

Cardiovascular Events in Users of Sildenafil: Results from First Phase of Prescription Event Monitoring in England

Academic journal article The Canadian Journal of Human Sexuality

Cardiovascular Events in Users of Sildenafil: Results from First Phase of Prescription Event Monitoring in England

Article excerpt

Shakir, A. W., Wilton, L.V., Boshier, A., Layton, D., & Heely, E. (2001). Cardiovascular events in users of sildenafil: results from first phase of prescription event monitoring in England. British Medical Journal, 322, 651-652.

Sildenafil, marketed under the brand name Viagra[TM], is a popular and effective prescription medication for the treatment of male erectile dysfunction. Sildenafil works by enhancing the smooth muscle relaxant effects of nitric oxide, a substance that is released locally in response to sexual arousal. The muscle relaxation allows blood to enter and pool in the penis, leading to erection. Because of it's interaction with the cardiovascular system, there has been concern that taking sildenafil may result in an increased risk for myocardial infarction (heart attack).

Shakir et al. used England's prescription event monitoring system to investigate possible side effects of sildenafil. General practitioners were sent questionnaires five months after giving a patient his first prescription for sildenafil. The questionnaire requested that the physician report any event that had occurred after the prescription had been issued. …

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