Academic journal article Environmental Health Perspectives

Health Effects of Chemical Contaminants in Drinking Water. (Fellowships, Grants, & Awards)

Academic journal article Environmental Health Perspectives

Health Effects of Chemical Contaminants in Drinking Water. (Fellowships, Grants, & Awards)

Article excerpt

Several of the contaminants on the U.S. Environmental Protection Agency's water contaminant candidate list are among those chemicals known to induce methemoglobin formation. There are a number of sensitive subpopulations that are more susceptible to methemoglobin formation than the general population.

This request for applications (RFA) solicits proposals on the susceptibility of sensitive populations to the acute effects of methemoglobin formation from contaminants in drinking water, as well as research on the dose--response characteristics of subpopulations susceptible to methemoglobin formation as compared to the normal population, and on whether the response to mixtures of exogenous methemoglobin inducers is additive or synergistic. Proposals might also consider species differences in metabolism of methemoglobin inducers, because species differences in metabolism may contribute to sensitivity. To better characterize the human health risk from aluminum, research is needed to determine factors that influence the occurrence of various aluminum complexes, the relative influence of such complexes on the distribution of aluminum in the body, and the dose-dependent contribution of such complexes to neurotoxic effects. …

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