Academic journal article Environmental Health Perspectives

Technologies for Closing DNA Sequence Gaps and Improving Methods for Obtaining the Sequence of Difficult-to-Sequence Regions. (Fellowships, Grants, & Awards)

Academic journal article Environmental Health Perspectives

Technologies for Closing DNA Sequence Gaps and Improving Methods for Obtaining the Sequence of Difficult-to-Sequence Regions. (Fellowships, Grants, & Awards)

Article excerpt

The National Human Genome Research Institute (NHGRI) invites applications to develop strategies and technologies for obtaining DNA sequence in the gaps that, due to limitations in available cloning and sequencing technology, will remain in essentially finished genomic sequence. Such gaps may arise from an inability to done a region in any available vector system or to obtain sequence from all or part of an available clone. Such gaps have been encountered in every large genome sequencing effort to date. NHGRI encourages the development of novel approaches to allow completion of the DNA sequence within the gaps left by current sequencing methods and to improve the efficiency of sequencing in genomic regions that have proved difficult to sequence.

The large-scale sequencing centers have provided lists of clones containing regions with gaps or DNA that was difficult to sequence, posted at http://www. nhgri.nih.gov/About_NHGRI/Der/gapPA.html. Investigators applying for this program announcement (PA) may use this information to find clones on which they may develop and demonstrate their strategy/technology. This PA is limited to proposals to develop and obtain proof of principle for new technologies.

Approximately $2 million is available for funding, and 5-10 awards may be made during the first year of the program, contingent upon the availability of funds and receipt of a sufficient number of high-quality applications. …

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